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- W2073594772 abstract "Objective An apparent excess of sex chromosome aneuploidies (XXY, XXX, and possibly XYY) has been reported in patients with adult-onset schizophrenia and with unspecified psychoses. This study describes the results of cytogenetic screening carried out for pediatric patients meeting DSM-III-R criteria for childhood-onset schizophrenia (COS) and a subgroup of patients with childhood-onset psychotic disorder not otherwise specified, provisionally labeled by the authors as multidimensionally impaired (MDI). Method From August 1990 to July 1997, karyotypes were determined for 66 neuroleptic-nonresponsive pediatric patients (28 MDI, 38 COS), referred to the National Institute of Mental Health for an inpatient treatment trial of clozapine. Results Four (6.1%) of 66 patients (3 MDI, 1 COS) were found to have sex chromosome anomalies (mosaic 47,XXY; 47,XXY; 47,XYY; mosaic 45,XO, respectively), which is higher than the expected rate of 1 per 426 children or 2.34 per 1,000 in the general population (4/66 versus 1/426, X2 = 19.2, df= 1, p = .00001). All cases had been previously undiagnosed. Conclusions These findings lend support to a hypothesis that a loss of balance of gene products on the sex chromosomes may predispose affected individuals to susceptibility to additional genetic and environmental insults that result in childhood-onset psychotic disorders. Karyotyping of children with psychotic disorders should be routine. J. Am. Acad. Child Adolesc. Psychiatry, 1998, 37(3):292–296." @default.
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- W2073594772 date "1998-03-01" @default.
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- W2073594772 title "Brief Report: Association of Sex Chromosome Anomalies With Childhood-Onset Psychotic Disorders" @default.
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- W2073594772 doi "https://doi.org/10.1097/00004583-199803000-00014" @default.
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