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• W2073598274 endingPage "35" @default.
• W2073598274 startingPage "21" @default.
• W2073598274 abstract "The search for new pharmacologically active compounds in drug discovery programmes often neglects biopharmaceutical properties as drug absorption. As a result, poor biopharmaceutical characteristics constitute a major reason for the low success rate for candidates in clinical development. Since the cost of drug development is many times larger than the cost of drug discovery, predictive methodologies aiding the selection of bioavailable drug candidates are of profound significance. This paper has been focussed on recent developments and applications of chromatographic systems, particularly those systems based on amphiphilic structures, in the frame of alternative approaches for estimating the transport properties of new drugs. The aim of this review is to take a critical look at the separations methods proposed for describing and predicting drug passive permeability across gastrointestinal tract and the skin." @default.
• W2073598274 created "2016-06-24" @default.
• W2073598274 creator A5029757082 @default.
• W2073598274 creator A5043911054 @default.
• W2073598274 creator A5070146407 @default.
• W2073598274 creator A5072490813 @default.
• W2073598274 creator A5082223167 @default.
• W2073598274 date "2003-11-01" @default.
• W2073598274 modified "2023-09-30" @default.
• W2073598274 title "Biopartitioning micellar separation methods: modelling drug absorption" @default.
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• W2073598274 doi "https://doi.org/10.1016/s1570-0232(03)00606-8" @default.
• W2073598274 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14630141" @default.

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