FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073598808> ?p ?o ?g. }

• W2073598808 endingPage "65" @default.
• W2073598808 startingPage "56" @default.
• W2073598808 abstract "While the Src family of protein tyrosine kinases (SFK), and the main ancillary molecules involved in their regulation, have been studied for many years, the details of their interplay are not fully understood and thus remain under active investigation. Additionally, new players that coordinate their regulation and direct their signalling cascades are also being uncovered, shedding new light on the complexity of these signalling networks. Through the utilization of novel interaction assays, several new interconnecting mediators that are helping to show the elegance of Src family kinase regulation have been discovered. This review outlines SFK regulation, the discovery of the Csk binding protein (Phosphoprotein Associated with Glycosphingolipid-enriched microdomains, Cbp/PAG), and its role in regulating SFK kinase activity status, as well as protein levels. Further, details of the methods used to identify this dual mode of regulation can be applied to delineate the full gamut of SH2/SH3-directed SFK pathways and, indeed, those of any tyrosine kinase. Using Lyn as a model SFK, we and others have shown that Cbp recruits negative regulators of COOH-terminal Src kinase (Csk)/Csk-like protein-tyrosine kinase (Ctk) after Lyn is activated and bound to Cbp. Lyn phosphorylates Cbp on multiple tyrosine residues, including two that can bind Lyn's SH2 domain with high affinity. Lyn also phosphorylates Y314, which recruits Csk/Ctk to phosphorylate Lyn at its Y508 negative site, allowing an inactive conformation to form. However, the pY508 site has a low affinity for Lyn's SH2 domain, while the Cbp sites have high affinity. Thus, until these Cbp sites are dephosphorylated, Lyn can remain active. Intriguingly, phosphorylated Y314 also binds the suppressor of cytokine signalling 1 (SOCS1), resulting in elevated ubiquitination and degradation of Lyn. Thus, a single phosphotyrosine residue within Cbp co-ordinates a two-phase process involving distinct negative regulatory pathways that allow inactivation, followed by degradation, of SFKs." @default.
• W2073598808 created "2016-06-24" @default.
• W2073598808 creator A5005403182 @default.
• W2073598808 date "2008-01-01" @default.
• W2073598808 modified "2023-10-04" @default.
• W2073598808 title "Src family kinases: Regulation of their activities, levels and identification of new pathways" @default.
• W2073598808 cites W1485667500 @default.
• W2073598808 cites W1548078808 @default.
• W2073598808 cites W1553517909 @default.
• W2073598808 cites W1594706458 @default.
• W2073598808 cites W1601798272 @default.
• W2073598808 cites W161143260 @default.
• W2073598808 cites W1964396270 @default.
• W2073598808 cites W1965712069 @default.
• W2073598808 cites W1966998035 @default.
• W2073598808 cites W1968423732 @default.
• W2073598808 cites W1969678324 @default.
• W2073598808 cites W1971160595 @default.
• W2073598808 cites W1977186059 @default.
• W2073598808 cites W1981096579 @default.
• W2073598808 cites W1981660923 @default.
• W2073598808 cites W1983293287 @default.
• W2073598808 cites W1986467673 @default.
• W2073598808 cites W1990915902 @default.
• W2073598808 cites W1991683855 @default.
• W2073598808 cites W1992009506 @default.
• W2073598808 cites W1995406360 @default.
• W2073598808 cites W1999306810 @default.
• W2073598808 cites W2003570140 @default.
• W2073598808 cites W2005261405 @default.
• W2073598808 cites W2011147958 @default.
• W2073598808 cites W2014096863 @default.
• W2073598808 cites W2017007375 @default.
• W2073598808 cites W2018434227 @default.
• W2073598808 cites W2019420747 @default.
• W2073598808 cites W2019987740 @default.
• W2073598808 cites W2022125301 @default.
• W2073598808 cites W2023187275 @default.
• W2073598808 cites W2024028178 @default.
• W2073598808 cites W2026522709 @default.
• W2073598808 cites W2027207299 @default.
• W2073598808 cites W2030205108 @default.
• W2073598808 cites W2032116260 @default.
• W2073598808 cites W2034152669 @default.
• W2073598808 cites W2034341688 @default.
• W2073598808 cites W2035782639 @default.
• W2073598808 cites W2038816853 @default.
• W2073598808 cites W2039998576 @default.
• W2073598808 cites W2044436100 @default.
• W2073598808 cites W2046311950 @default.
• W2073598808 cites W2054144845 @default.
• W2073598808 cites W2054222279 @default.
• W2073598808 cites W2059552745 @default.
• W2073598808 cites W2061050157 @default.
• W2073598808 cites W2065289702 @default.
• W2073598808 cites W2070696612 @default.
• W2073598808 cites W2072659663 @default.
• W2073598808 cites W2073300307 @default.
• W2073598808 cites W2075121503 @default.
• W2073598808 cites W2075265463 @default.
• W2073598808 cites W2075438429 @default.
• W2073598808 cites W2080568049 @default.
• W2073598808 cites W2085580043 @default.
• W2073598808 cites W2089291239 @default.
• W2073598808 cites W2089379007 @default.
• W2073598808 cites W2100869656 @default.
• W2073598808 cites W2113071946 @default.
• W2073598808 cites W2114356070 @default.
• W2073598808 cites W2118738797 @default.
• W2073598808 cites W2138778824 @default.
• W2073598808 cites W2148006813 @default.
• W2073598808 cites W2152624886 @default.
• W2073598808 cites W2156480395 @default.
• W2073598808 cites W2158395929 @default.
• W2073598808 cites W2160675888 @default.
• W2073598808 cites W2164682544 @default.
• W2073598808 cites W2169584935 @default.
• W2073598808 cites W2170218211 @default.
• W2073598808 cites W2171480972 @default.
• W2073598808 cites W2408339784 @default.
• W2073598808 cites W317592431 @default.
• W2073598808 cites W4251683570 @default.
• W2073598808 cites W4254630790 @default.
• W2073598808 cites W658767352 @default.
• W2073598808 doi "https://doi.org/10.1016/j.bbapap.2007.08.012" @default.
• W2073598808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17905674" @default.
• W2073598808 hasPublicationYear "2008" @default.
• W2073598808 type Work @default.
• W2073598808 sameAs 2073598808 @default.
• W2073598808 citedByCount "286" @default.
• W2073598808 countsByYear W20735988082012 @default.
• W2073598808 countsByYear W20735988082013 @default.
• W2073598808 countsByYear W20735988082014 @default.
• W2073598808 countsByYear W20735988082015 @default.
• W2073598808 countsByYear W20735988082016 @default.
• W2073598808 countsByYear W20735988082017 @default.
• W2073598808 countsByYear W20735988082018 @default.
• W2073598808 countsByYear W20735988082019 @default.

• next