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• W2073607810 abstract "Mouse embryonic fibroblasts (MEFs) are commonly grown in cell culture and are known to enter senescence after a low number of passages as a result of oxidative stress. Oxidative stress has also been suggested to promote centrosome disruption; however, the contribution of this organelle to senescence is poorly understood. Therefore, this study aimed to assess the role of the centrosome in oxidative stress induced-senescence using MEFs as a model. We demonstrate here that coincident with the entry of late-passage MEFs into senescence, there was an increase in supernumerary centrosomes, most likely due to centrosome fragmentation. In addition, disrupting the centrosome in early-passage MEFs by depletion of neural precursor cell expressed developmentally downregulated gene 1 (NEDD1) also resulted in centrosomal fragmentation and subsequent premature entry into senescence. These data show that a loss of centrosomal integrity may contribute to the entry of MEFs into senescence in culture, and that centrosomal disruption can cause senescence." @default.
• W2073607810 created "2016-06-24" @default.
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• W2073607810 date "2010-04-15" @default.
• W2073607810 modified "2023-10-08" @default.
• W2073607810 title "A potential role for NEDD1 and the centrosome in senescence of mouse embryonic fibroblasts" @default.
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• W2073607810 doi "https://doi.org/10.1038/cddis.2010.12" @default.
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