Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073609832> ?p ?o ?g. }
- W2073609832 endingPage "733" @default.
- W2073609832 startingPage "728" @default.
- W2073609832 abstract "Growth of cells in vitro in the presence of fatty acids can alter the membrane composition and hence fluidity and permeability. Exposure of both doxorubicin (2780AD) and cisplatin (2780CP) resistant human ovarian cell lines to non-toxic concentrations of polyunsaturated fatty acids (gamma-linolenic acid and eicosapentaenoic acid) either before or during exposure to the cytotoxic drug did not modulate drug sensitivity. However, the fatty acids were toxic in their own right. Whilst the ovarian cell lines 2780AD and 2780CP showed a small degree of cross resistance to both fatty acids the doxorubicin resistant breast cell line MCF7/Adr was slightly more sensitive than MCF7. When the interactions between the polyunsaturated fatty acids and cytotoxic drugs were analysed by the isobologram method the toxicities were shown to be additive. The combination of polyunsaturated fatty acids and cytotoxic drugs may have clinical potential provided that the normal tissue toxicities of the two treatments are not additive." @default.
- W2073609832 created "2016-06-24" @default.
- W2073609832 creator A5017274582 @default.
- W2073609832 creator A5038254746 @default.
- W2073609832 creator A5055065103 @default.
- W2073609832 date "1993-04-01" @default.
- W2073609832 modified "2023-10-17" @default.
- W2073609832 title "Effect of polyunsaturated fatty acids on the drug sensitivity of human tumour cell lines resistant to either cisplatin or doxorubicin" @default.
- W2073609832 cites W104982173 @default.
- W2073609832 cites W1520124386 @default.
- W2073609832 cites W1532410496 @default.
- W2073609832 cites W1575044740 @default.
- W2073609832 cites W1907854530 @default.
- W2073609832 cites W1914653453 @default.
- W2073609832 cites W1965059247 @default.
- W2073609832 cites W1977236629 @default.
- W2073609832 cites W1981148289 @default.
- W2073609832 cites W1997250289 @default.
- W2073609832 cites W1998028162 @default.
- W2073609832 cites W2001473164 @default.
- W2073609832 cites W2005579323 @default.
- W2073609832 cites W2008453038 @default.
- W2073609832 cites W2028287156 @default.
- W2073609832 cites W2032635518 @default.
- W2073609832 cites W2051405219 @default.
- W2073609832 cites W2065704766 @default.
- W2073609832 cites W2072095575 @default.
- W2073609832 cites W2079571554 @default.
- W2073609832 cites W2099722729 @default.
- W2073609832 cites W2102314850 @default.
- W2073609832 cites W2105023135 @default.
- W2073609832 cites W2107504037 @default.
- W2073609832 cites W2117861555 @default.
- W2073609832 cites W2320052151 @default.
- W2073609832 cites W2339809149 @default.
- W2073609832 cites W2461650493 @default.
- W2073609832 cites W2472594290 @default.
- W2073609832 cites W257760749 @default.
- W2073609832 cites W4256032850 @default.
- W2073609832 cites W4290394190 @default.
- W2073609832 cites W59969523 @default.
- W2073609832 cites W76267410 @default.
- W2073609832 cites W1892264770 @default.
- W2073609832 doi "https://doi.org/10.1038/bjc.1993.133" @default.
- W2073609832 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1968342" @default.
- W2073609832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8385976" @default.
- W2073609832 hasPublicationYear "1993" @default.
- W2073609832 type Work @default.
- W2073609832 sameAs 2073609832 @default.
- W2073609832 citedByCount "47" @default.
- W2073609832 countsByYear W20736098322012 @default.
- W2073609832 countsByYear W20736098322013 @default.
- W2073609832 countsByYear W20736098322014 @default.
- W2073609832 countsByYear W20736098322015 @default.
- W2073609832 countsByYear W20736098322016 @default.
- W2073609832 countsByYear W20736098322020 @default.
- W2073609832 countsByYear W20736098322021 @default.
- W2073609832 countsByYear W20736098322022 @default.
- W2073609832 crossrefType "journal-article" @default.
- W2073609832 hasAuthorship W2073609832A5017274582 @default.
- W2073609832 hasAuthorship W2073609832A5038254746 @default.
- W2073609832 hasAuthorship W2073609832A5055065103 @default.
- W2073609832 hasBestOaLocation W20736098322 @default.
- W2073609832 hasConcept C109316439 @default.
- W2073609832 hasConcept C126322002 @default.
- W2073609832 hasConcept C154317977 @default.
- W2073609832 hasConcept C185592680 @default.
- W2073609832 hasConcept C19038510 @default.
- W2073609832 hasConcept C202751555 @default.
- W2073609832 hasConcept C2776091944 @default.
- W2073609832 hasConcept C2776694085 @default.
- W2073609832 hasConcept C2777171753 @default.
- W2073609832 hasConcept C2778239845 @default.
- W2073609832 hasConcept C2779311130 @default.
- W2073609832 hasConcept C2781303535 @default.
- W2073609832 hasConcept C543025807 @default.
- W2073609832 hasConcept C54355233 @default.
- W2073609832 hasConcept C55493867 @default.
- W2073609832 hasConcept C71924100 @default.
- W2073609832 hasConcept C81885089 @default.
- W2073609832 hasConcept C86803240 @default.
- W2073609832 hasConcept C98274493 @default.
- W2073609832 hasConceptScore W2073609832C109316439 @default.
- W2073609832 hasConceptScore W2073609832C126322002 @default.
- W2073609832 hasConceptScore W2073609832C154317977 @default.
- W2073609832 hasConceptScore W2073609832C185592680 @default.
- W2073609832 hasConceptScore W2073609832C19038510 @default.
- W2073609832 hasConceptScore W2073609832C202751555 @default.
- W2073609832 hasConceptScore W2073609832C2776091944 @default.
- W2073609832 hasConceptScore W2073609832C2776694085 @default.
- W2073609832 hasConceptScore W2073609832C2777171753 @default.
- W2073609832 hasConceptScore W2073609832C2778239845 @default.
- W2073609832 hasConceptScore W2073609832C2779311130 @default.
- W2073609832 hasConceptScore W2073609832C2781303535 @default.
- W2073609832 hasConceptScore W2073609832C543025807 @default.
- W2073609832 hasConceptScore W2073609832C54355233 @default.
- W2073609832 hasConceptScore W2073609832C55493867 @default.
- W2073609832 hasConceptScore W2073609832C71924100 @default.