FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073611690> ?p ?o ?g. }

• W2073611690 endingPage "99" @default.
• W2073611690 startingPage "88" @default.
• W2073611690 abstract "The paper reports a study on the reactions of grass pea (Lathyrus sativus) amine oxidase (GPAO) with several aliphatic diamines. The influence of the chain length and of unsaturations in the molecules was examined. Kinetic measurements confirmed that trans-, i.e., (E)-2-butene-1,4-diamine (TDABE) and cis-, i.e., (Z)-2-butene-1,4-diamine (CDABE) could be classified as good substrates. Propane-1,3-diamine (DAP) and propene-1,3-diamine (DAPE) were only weakly oxidized, whereas 1,3-diamino-2-propanol (DAPL) was not utilized as a substrate. Contrary to the inactivator 2-butyne-1,4-diamine (DABI), DAPE was shown to be only a competitive inhibitor. DAP itself did not inhibit the catalytic activity. Irreversible inhibition of the activity occurred only after the incubation of GPAO with DABI; other diamines were without this effect. Differential pulse polarography and chromatofocusing confirmed that the aminoaldehyde product of DABI oxidation binds to the enzyme. Activity assay of pea aminoaldehyde dehydrogenase enabled us to detect the products of the oxidation of TDABE, CDABE, and DAP by GPAO. As the product of DAP oxidation, 3-amino-propanal (APAL) was detected by mass spectrometry and confirmed to be a potent noncompetitive inhibitor of GPAO. The absorption changes that occurred in the course of the reaction of GPAO with the diamines were investigated using rapid-scanning spectrophotometry. DABI, TDABE, CDABE, DAP, and DAPE reacted with GPAO providing characteristic maxima of the Cu(I)-semiquinolamine species that is formed in the catalytic cycle. The results presented here confirm that with the exception of DAPL, all the studied diamines could be classified as GPAO substrates, but only DABI can be considered as a mechanism-based inhibitor." @default.
• W2073611690 created "2016-06-24" @default.
• W2073611690 creator A5000518502 @default.
• W2073611690 creator A5017978950 @default.
• W2073611690 creator A5050518858 @default.
• W2073611690 creator A5051710329 @default.
• W2073611690 creator A5056588567 @default.
• W2073611690 date "2000-12-01" @default.
• W2073611690 modified "2023-10-18" @default.
• W2073611690 title "A Study on the Reactions of Plant Copper Amine Oxidase with C3 and C4 Aliphatic Diamines" @default.
• W2073611690 cites W1503415169 @default.
• W2073611690 cites W1816586868 @default.
• W2073611690 cites W1975890951 @default.
• W2073611690 cites W1977398169 @default.
• W2073611690 cites W1986070397 @default.
• W2073611690 cites W1996603987 @default.
• W2073611690 cites W1999954297 @default.
• W2073611690 cites W2005489176 @default.
• W2073611690 cites W2005575697 @default.
• W2073611690 cites W2006148837 @default.
• W2073611690 cites W2014281089 @default.
• W2073611690 cites W2023756858 @default.
• W2073611690 cites W2034109636 @default.
• W2073611690 cites W2036835190 @default.
• W2073611690 cites W2050252463 @default.
• W2073611690 cites W2050630962 @default.
• W2073611690 cites W2053193585 @default.
• W2073611690 cites W2054420610 @default.
• W2073611690 cites W2056587289 @default.
• W2073611690 cites W2064575020 @default.
• W2073611690 cites W2074711222 @default.
• W2073611690 cites W2074852848 @default.
• W2073611690 cites W2079855029 @default.
• W2073611690 cites W2083234939 @default.
• W2073611690 cites W2087347863 @default.
• W2073611690 cites W2116838198 @default.
• W2073611690 cites W2144261066 @default.
• W2073611690 cites W2152501306 @default.
• W2073611690 cites W2168832846 @default.
• W2073611690 cites W2198649898 @default.
• W2073611690 cites W2200965106 @default.
• W2073611690 cites W2305607250 @default.
• W2073611690 cites W4253776870 @default.
• W2073611690 cites W70792191 @default.
• W2073611690 doi "https://doi.org/10.1006/abbi.2000.2081" @default.
• W2073611690 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11147840" @default.
• W2073611690 hasPublicationYear "2000" @default.
• W2073611690 type Work @default.
• W2073611690 sameAs 2073611690 @default.
• W2073611690 citedByCount "16" @default.
• W2073611690 countsByYear W20736116902012 @default.
• W2073611690 countsByYear W20736116902019 @default.
• W2073611690 crossrefType "journal-article" @default.
• W2073611690 hasAuthorship W2073611690A5000518502 @default.
• W2073611690 hasAuthorship W2073611690A5017978950 @default.
• W2073611690 hasAuthorship W2073611690A5050518858 @default.
• W2073611690 hasAuthorship W2073611690A5051710329 @default.
• W2073611690 hasAuthorship W2073611690A5056588567 @default.
• W2073611690 hasConcept C111368507 @default.
• W2073611690 hasConcept C117001961 @default.
• W2073611690 hasConcept C127313418 @default.
• W2073611690 hasConcept C131779359 @default.
• W2073611690 hasConcept C13965031 @default.
• W2073611690 hasConcept C155647269 @default.
• W2073611690 hasConcept C161790260 @default.
• W2073611690 hasConcept C178790620 @default.
• W2073611690 hasConcept C181199279 @default.
• W2073611690 hasConcept C185592680 @default.
• W2073611690 hasConcept C2776829962 @default.
• W2073611690 hasConcept C2777289219 @default.
• W2073611690 hasConcept C2779053737 @default.
• W2073611690 hasConcept C2780871995 @default.
• W2073611690 hasConcept C71240020 @default.
• W2073611690 hasConcept C96294017 @default.
• W2073611690 hasConceptScore W2073611690C111368507 @default.
• W2073611690 hasConceptScore W2073611690C117001961 @default.
• W2073611690 hasConceptScore W2073611690C127313418 @default.
• W2073611690 hasConceptScore W2073611690C131779359 @default.
• W2073611690 hasConceptScore W2073611690C13965031 @default.
• W2073611690 hasConceptScore W2073611690C155647269 @default.
• W2073611690 hasConceptScore W2073611690C161790260 @default.
• W2073611690 hasConceptScore W2073611690C178790620 @default.
• W2073611690 hasConceptScore W2073611690C181199279 @default.
• W2073611690 hasConceptScore W2073611690C185592680 @default.
• W2073611690 hasConceptScore W2073611690C2776829962 @default.
• W2073611690 hasConceptScore W2073611690C2777289219 @default.
• W2073611690 hasConceptScore W2073611690C2779053737 @default.
• W2073611690 hasConceptScore W2073611690C2780871995 @default.
• W2073611690 hasConceptScore W2073611690C71240020 @default.
• W2073611690 hasConceptScore W2073611690C96294017 @default.
• W2073611690 hasIssue "1" @default.
• W2073611690 hasLocation W20736116901 @default.
• W2073611690 hasLocation W20736116902 @default.
• W2073611690 hasOpenAccess W2073611690 @default.
• W2073611690 hasPrimaryLocation W20736116901 @default.
• W2073611690 hasRelatedWork W165783144 @default.
• W2073611690 hasRelatedWork W1981987410 @default.
• W2073611690 hasRelatedWork W1983960538 @default.

• next