FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073616129> ?p ?o ?g. }

• W2073616129 endingPage "1601" @default.
• W2073616129 startingPage "1588" @default.
• W2073616129 abstract "Paclitaxel (Taxol) has been successfully combined with the monoclonal antibody trastuzumab (Herceptin) in the treatment of ErbB2 overexpressing cancers. However, this combination therapy showed an unexpected synergistic increase in cardiac dysfunction. We have studied the mechanisms of paclitaxel/anti-ErbB2 cardiotoxicity in adult rat ventricular myocytes (ARVM). Myofibrillar organization was assessed by immunofluorescence microscopy and cell viability was tested by the TUNEL-, LDH- and MTT-assay. Oxidative stress was measured by DCF-fluorescence and myocyte contractile function by video edge-detection and fura-2 fluorescence. Treatment of ARVM with paclitaxel or antibodies to ErbB2 caused a significant increase in myofilament degradation, similarly as observed with an inhibitor of MAPK-signaling, but not apoptosis, necrosis or changes in mitochondrial activity. Paclitaxel-treatment and anti-ErbB2 reduced Erk1/2 phosphorylation. Paclitaxel increased diastolic calcium, shortened relaxation time and reduced fractional shortening in combination with anti-ErbB2. A minor increase in oxidative stress by paclitaxel or anti-ErbB2 was found. We conclude, that concomitant inhibition of ErbB2 receptors and paclitaxel treatment has an additive worsening effect on adult cardiomyocytes, mainly discernible in changes of myofibrillar structure and function, but in the absence of cell death. A potential mechanism is the modulation of the MAPK/Erk1/2 signaling by both drugs." @default.
• W2073616129 created "2016-06-24" @default.
• W2073616129 creator A5011610803 @default.
• W2073616129 creator A5012817631 @default.
• W2073616129 creator A5022974887 @default.
• W2073616129 creator A5043681452 @default.
• W2073616129 creator A5078248427 @default.
• W2073616129 creator A5084523184 @default.
• W2073616129 date "2007-05-01" @default.
• W2073616129 modified "2023-10-12" @default.
• W2073616129 title "Inhibition of ErbB2/neuregulin signaling augments paclitaxel-induced cardiotoxicity in adult ventricular myocytes" @default.
• W2073616129 cites W1964321121 @default.
• W2073616129 cites W1972237278 @default.
• W2073616129 cites W1978783044 @default.
• W2073616129 cites W1982210988 @default.
• W2073616129 cites W1985831209 @default.
• W2073616129 cites W1987019905 @default.
• W2073616129 cites W1994304154 @default.
• W2073616129 cites W1994633980 @default.
• W2073616129 cites W2005889240 @default.
• W2073616129 cites W2014891807 @default.
• W2073616129 cites W2016656995 @default.
• W2073616129 cites W2024651005 @default.
• W2073616129 cites W2026238154 @default.
• W2073616129 cites W2030893402 @default.
• W2073616129 cites W2041342949 @default.
• W2073616129 cites W2041375606 @default.
• W2073616129 cites W2042190557 @default.
• W2073616129 cites W2042673628 @default.
• W2073616129 cites W2042960758 @default.
• W2073616129 cites W2045332245 @default.
• W2073616129 cites W2048762356 @default.
• W2073616129 cites W2050674912 @default.
• W2073616129 cites W2059487482 @default.
• W2073616129 cites W2064157036 @default.
• W2073616129 cites W2069494381 @default.
• W2073616129 cites W2073127574 @default.
• W2073616129 cites W2080673878 @default.
• W2073616129 cites W2081342132 @default.
• W2073616129 cites W2087061669 @default.
• W2073616129 cites W2090821063 @default.
• W2073616129 cites W2099545363 @default.
• W2073616129 cites W2102380466 @default.
• W2073616129 cites W2103353315 @default.
• W2073616129 cites W2110540881 @default.
• W2073616129 cites W2113504041 @default.
• W2073616129 cites W2116164394 @default.
• W2073616129 cites W2121708608 @default.
• W2073616129 cites W2149908785 @default.
• W2073616129 cites W2151582019 @default.
• W2073616129 cites W2159900833 @default.
• W2073616129 cites W2169606301 @default.
• W2073616129 cites W2173342501 @default.
• W2073616129 cites W2318605753 @default.
• W2073616129 doi "https://doi.org/10.1016/j.yexcr.2007.02.007" @default.
• W2073616129 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17400210" @default.
• W2073616129 hasPublicationYear "2007" @default.
• W2073616129 type Work @default.
• W2073616129 sameAs 2073616129 @default.
• W2073616129 citedByCount "66" @default.
• W2073616129 countsByYear W20736161292012 @default.
• W2073616129 countsByYear W20736161292013 @default.
• W2073616129 countsByYear W20736161292014 @default.
• W2073616129 countsByYear W20736161292015 @default.
• W2073616129 countsByYear W20736161292016 @default.
• W2073616129 countsByYear W20736161292017 @default.
• W2073616129 countsByYear W20736161292018 @default.
• W2073616129 countsByYear W20736161292019 @default.
• W2073616129 countsByYear W20736161292020 @default.
• W2073616129 countsByYear W20736161292021 @default.
• W2073616129 countsByYear W20736161292022 @default.
• W2073616129 countsByYear W20736161292023 @default.
• W2073616129 crossrefType "journal-article" @default.
• W2073616129 hasAuthorship W2073616129A5011610803 @default.
• W2073616129 hasAuthorship W2073616129A5012817631 @default.
• W2073616129 hasAuthorship W2073616129A5022974887 @default.
• W2073616129 hasAuthorship W2073616129A5043681452 @default.
• W2073616129 hasAuthorship W2073616129A5078248427 @default.
• W2073616129 hasAuthorship W2073616129A5084523184 @default.
• W2073616129 hasConcept C121608353 @default.
• W2073616129 hasConcept C126322002 @default.
• W2073616129 hasConcept C134018914 @default.
• W2073616129 hasConcept C190283241 @default.
• W2073616129 hasConcept C207200792 @default.
• W2073616129 hasConcept C2776151105 @default.
• W2073616129 hasConcept C2776694085 @default.
• W2073616129 hasConcept C2777292972 @default.
• W2073616129 hasConcept C2778233292 @default.
• W2073616129 hasConcept C54355233 @default.
• W2073616129 hasConcept C55493867 @default.
• W2073616129 hasConcept C71924100 @default.
• W2073616129 hasConcept C86803240 @default.
• W2073616129 hasConcept C98274493 @default.
• W2073616129 hasConceptScore W2073616129C121608353 @default.
• W2073616129 hasConceptScore W2073616129C126322002 @default.
• W2073616129 hasConceptScore W2073616129C134018914 @default.
• W2073616129 hasConceptScore W2073616129C190283241 @default.
• W2073616129 hasConceptScore W2073616129C207200792 @default.

• next