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• W2073619242 abstract "The efficient delivery of therapeutic gene into cells of interest is a critical challenge to broad application of non-viral vectors. The approach of introducing ligands that lead gene vectors to target caveolae-mediated endocytosis on nanoparticle surface might serve as a promising strategy for the effective gene transfection. Recently, in an attempt to enhance the possibility of caveolae-mediated endocytosis, we fabricated a peptide-targeted gene vector for highly efficient receptor-mediated intracellular delivery. Cyclic Asn-Gly-Arg (cNGR) peptide was used to target gene loaded poly(lactic acid)–poly(ethylene glycol) nanoparticles (PLA–PEG NPs) to HUVEC over-expressing CD13. Using 6-lauroxyhexyl lysinate (LHLN) as cationic surfactant, cNGR modified PLA–PEG NPs (cNGR–PEG–PLA NPs) were capable of complexing and compacting DNA into homogeneous small-sized complexes (< 200 nm) with positive charge (~ 10 mV). Fortunately, the results of in vitro cellular uptake tests and mechanism studies were consistent with our original hypothesis. The cNGR peptide presented on nanoparticles' surface could specifically mediate the fast and efficient internalization of cNGR–PEG–PLA NPs into HUVEC. Moreover, free cNGR inhibited their intracellular uptake into HUVEC revealing the mechanism of receptor-mediated endocytosis. Furthermore, the inspiring results of the mechanism studies and transfection assays demonstrated that caveolae-mediated endocytosis was indeed mainly involved in the internalization of cNGR–PEG–PLA NPs into HUVEC and led to significant gene transfection efficiency in contrast with cNGR non-modified PLA–PEG NPs. Given such encouraging and favorable properties including biocompatibility, high transfer efficiency, low cytotoxicity, and fast uptake by nondestructive endocytic pathways, cNGR–PEG–PLA NPs could be a promising carrier for the intracellular delivery of therapeutic agents." @default.
• W2073619242 created "2016-06-24" @default.
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• W2073619242 date "2011-04-01" @default.
• W2073619242 modified "2023-10-18" @default.
• W2073619242 title "Enhanced gene transfection efficiency in CD13-positive vascular endothelial cells with targeted poly(lactic acid)–poly(ethylene glycol) nanoparticles through caveolae-mediated endocytosis" @default.
• W2073619242 cites W1965600613 @default.
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• W2073619242 cites W1996686306 @default.
• W2073619242 cites W2003110090 @default.
• W2073619242 cites W2004573841 @default.
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• W2073619242 cites W2008410018 @default.
• W2073619242 cites W2009307175 @default.
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• W2073619242 cites W2026523172 @default.
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• W2073619242 cites W2028531434 @default.
• W2073619242 cites W2030141620 @default.
• W2073619242 cites W2034906167 @default.
• W2073619242 cites W2037272596 @default.
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• W2073619242 cites W2051212988 @default.
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• W2073619242 cites W2090699031 @default.
• W2073619242 cites W2091077321 @default.
• W2073619242 cites W2093231351 @default.
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• W2073619242 doi "https://doi.org/10.1016/j.jconrel.2011.02.027" @default.
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