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• W2073619468 abstract "Metabolism of artemisinin derivatives, which are antimalarial sesquiterpenes, appeared to lead to the production of the more polar metabolites in general. Presnece of the endoperoxide moiety in the A/B ring structures seem crucial for the expression fo antimalarial activity of these compounds. Microbial models served as effective predictors for the mammalain metabolism of artemisinin derivatives as well as producing quantities of metabolites for reference standards and structure elucidation studies. Combination of 2D-NMR and Thermospray HPLC/MS techniques was very useful for the structure elucidation of metabolites." @default.
• W2073619468 created "2016-06-24" @default.
• W2073619468 creator A5009660847 @default.
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• W2073619468 date "1990-01-01" @default.
• W2073619468 modified "2023-10-03" @default.
• W2073619468 title "Metabolism of antimalarial sesquiterpene lactones" @default.
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• W2073619468 doi "https://doi.org/10.1016/0163-7258(90)90053-5" @default.
• W2073619468 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2084705" @default.
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