FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073622804> ?p ?o ?g. }

• W2073622804 endingPage "222" @default.
• W2073622804 startingPage "211" @default.
• W2073622804 abstract "Theileria annulata infects bovine leucocytes and results in their reversible transformation such that they become immortalised and metastatic. The present study describes parasite-induced changes in host cell gene expression which have a direct bearing on this transformation process. T. annulata-infected leucocytes produce a number of novel metalloproteinase activities. One of these, previously called B1, is a 97-kDa protein which is secreted in large amounts and has been purified from protein-free, conditioned medium. An antiserum to this enzyme was used to isolate a cDNA clone. The predicted protein sequence of B1 is 81% identical to human matrix metalloproteinase 9 (MMP9), demonstrating that it is the bovine homologue of this enzyme. RNAase protection assays demonstrated that the MMP9 activity, unique to infected cells, is due to increased MMP9 mRNA levels. We also assayed the levels of transcription factor AP-1 and demonstrated that it was constitutively present in increased amounts in Theileria-infected cells. In addition we assayed the level of mRNA encoding c-Fos, a common component of AP-1 and observed that it was indeed up-regulated in infected cells. Since AP-1 is implicated in the control of the cell cycle, and MMP9 can confer metastatic properties, these results are of considerable significance with respect to the transformed phenotype induced by Theileria infection." @default.
• W2073622804 created "2016-06-24" @default.
• W2073622804 creator A5010311974 @default.
• W2073622804 date "1995-02-01" @default.
• W2073622804 modified "2023-09-24" @default.
• W2073622804 title "Infection with Theileria annulata induces expression of matrix metalloproteinase 9 and transcription factor AP-1 in bovine leucocytes" @default.
• W2073622804 cites W12952247 @default.
• W2073622804 cites W1458634991 @default.
• W2073622804 cites W1511688323 @default.
• W2073622804 cites W1516457342 @default.
• W2073622804 cites W1546229037 @default.
• W2073622804 cites W1546294290 @default.
• W2073622804 cites W1546619202 @default.
• W2073622804 cites W1594700207 @default.
• W2073622804 cites W1596645541 @default.
• W2073622804 cites W1686570440 @default.
• W2073622804 cites W183310135 @default.
• W2073622804 cites W1881196492 @default.
• W2073622804 cites W1970516412 @default.
• W2073622804 cites W1970586710 @default.
• W2073622804 cites W1977956900 @default.
• W2073622804 cites W1979404910 @default.
• W2073622804 cites W1980480613 @default.
• W2073622804 cites W2009310436 @default.
• W2073622804 cites W2015654373 @default.
• W2073622804 cites W2018563836 @default.
• W2073622804 cites W2023711373 @default.
• W2073622804 cites W2035990675 @default.
• W2073622804 cites W2045103636 @default.
• W2073622804 cites W2050717506 @default.
• W2073622804 cites W2052977964 @default.
• W2073622804 cites W2062784484 @default.
• W2073622804 cites W2077309544 @default.
• W2073622804 cites W2078583523 @default.
• W2073622804 cites W2081135713 @default.
• W2073622804 cites W2081687035 @default.
• W2073622804 cites W2094646101 @default.
• W2073622804 cites W2109658199 @default.
• W2073622804 cites W2128635872 @default.
• W2073622804 cites W2138270253 @default.
• W2073622804 cites W2144634347 @default.
• W2073622804 cites W2184551474 @default.
• W2073622804 cites W2467806229 @default.
• W2073622804 cites W2576734941 @default.
• W2073622804 cites W3114686187 @default.
• W2073622804 cites W610062301 @default.
• W2073622804 cites W615273299 @default.
• W2073622804 cites W63477079 @default.
• W2073622804 cites W643035040 @default.
• W2073622804 doi "https://doi.org/10.1016/0166-6851(94)00216-a" @default.
• W2073622804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7770085" @default.
• W2073622804 hasPublicationYear "1995" @default.
• W2073622804 type Work @default.
• W2073622804 sameAs 2073622804 @default.
• W2073622804 citedByCount "62" @default.
• W2073622804 countsByYear W20736228042012 @default.
• W2073622804 countsByYear W20736228042013 @default.
• W2073622804 countsByYear W20736228042014 @default.
• W2073622804 countsByYear W20736228042015 @default.
• W2073622804 countsByYear W20736228042016 @default.
• W2073622804 countsByYear W20736228042017 @default.
• W2073622804 countsByYear W20736228042018 @default.
• W2073622804 countsByYear W20736228042020 @default.
• W2073622804 countsByYear W20736228042021 @default.
• W2073622804 countsByYear W20736228042022 @default.
• W2073622804 crossrefType "journal-article" @default.
• W2073622804 hasAuthorship W2073622804A5010311974 @default.
• W2073622804 hasConcept C104317684 @default.
• W2073622804 hasConcept C105580179 @default.
• W2073622804 hasConcept C109523444 @default.
• W2073622804 hasConcept C127561419 @default.
• W2073622804 hasConcept C136764020 @default.
• W2073622804 hasConcept C153911025 @default.
• W2073622804 hasConcept C159047783 @default.
• W2073622804 hasConcept C187882448 @default.
• W2073622804 hasConcept C204241405 @default.
• W2073622804 hasConcept C2775997469 @default.
• W2073622804 hasConcept C2776111823 @default.
• W2073622804 hasConcept C41008148 @default.
• W2073622804 hasConcept C54355233 @default.
• W2073622804 hasConcept C55493867 @default.
• W2073622804 hasConcept C55728118 @default.
• W2073622804 hasConcept C71928629 @default.
• W2073622804 hasConcept C81885089 @default.
• W2073622804 hasConcept C86803240 @default.
• W2073622804 hasConceptScore W2073622804C104317684 @default.
• W2073622804 hasConceptScore W2073622804C105580179 @default.
• W2073622804 hasConceptScore W2073622804C109523444 @default.
• W2073622804 hasConceptScore W2073622804C127561419 @default.
• W2073622804 hasConceptScore W2073622804C136764020 @default.
• W2073622804 hasConceptScore W2073622804C153911025 @default.
• W2073622804 hasConceptScore W2073622804C159047783 @default.
• W2073622804 hasConceptScore W2073622804C187882448 @default.
• W2073622804 hasConceptScore W2073622804C204241405 @default.
• W2073622804 hasConceptScore W2073622804C2775997469 @default.
• W2073622804 hasConceptScore W2073622804C2776111823 @default.
• W2073622804 hasConceptScore W2073622804C41008148 @default.
• W2073622804 hasConceptScore W2073622804C54355233 @default.

• next