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- W2073627261 abstract "ACE2 (angiotensin-converting enzyme 2) counterbalances the actions of ACE (angiotensin-converting enzyme) by metabolizing its catalytic product, the vasoactive and fibrogenic peptide AngII (angiotensin II), into Ang-(1–7) [angiotensin-(1–7)]. Enhanced ACE2 expression may be protective in diabetes, cardiovascular disease and cancer. However, relatively little is known about the specific physiological factors regulating ACE2 expression. In the present paper, we show, by Western blotting and qPCR (quantitative real-time PCR), that ACE2 expression is increased under conditions of cell stress, including hypoxic conditions, IL (interleukin)-1β treatment and treatment with the AMP mimic AICAR (5-amino-4-imidazolecarboxamide riboside). The NAD+-dependent deacetylase SIRT1 (silent information regulator T1) was found to be up-regulated after AICAR treatment but, conversely, was down-regulated after IL-1β treatment. ChIP analysis demonstrated that SIRT1 bound to the ACE2 promoter and that binding was increased after AICAR treatment, but decreased after IL-1β treatment. Inhibition of SIRT1 activity ablated the AICAR-induced increase in ACE2. In conclusion, we have established that the expression of the ACE2 transcript is controlled by the activity of SIRT1 under conditions of energy stress." @default.
- W2073627261 created "2016-06-24" @default.
- W2073627261 creator A5026798553 @default.
- W2073627261 creator A5051042418 @default.
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- W2073627261 date "2013-12-11" @default.
- W2073627261 modified "2023-10-15" @default.
- W2073627261 title "Epigenetic regulation of angiotensin-converting enzyme 2 (ACE2) by SIRT1 under conditions of cell energy stress" @default.
- W2073627261 cites W1581300995 @default.
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- W2073627261 cites W1964893196 @default.
- W2073627261 cites W1965289779 @default.
- W2073627261 cites W1965837277 @default.
- W2073627261 cites W1966238900 @default.
- W2073627261 cites W1966734666 @default.
- W2073627261 cites W1968659654 @default.
- W2073627261 cites W1974985368 @default.
- W2073627261 cites W1981013779 @default.
- W2073627261 cites W1981179781 @default.
- W2073627261 cites W1984382435 @default.
- W2073627261 cites W1988170133 @default.
- W2073627261 cites W1990931780 @default.
- W2073627261 cites W1995069275 @default.
- W2073627261 cites W1998771362 @default.
- W2073627261 cites W2000047954 @default.
- W2073627261 cites W2002765492 @default.
- W2073627261 cites W2015022497 @default.
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- W2073627261 cites W2016779121 @default.
- W2073627261 cites W2017614891 @default.
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- W2073627261 cites W2019080454 @default.
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- W2073627261 doi "https://doi.org/10.1042/cs20130291" @default.
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