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• W2073636675 abstract "Objectives The incidence of chemotherapy induced peripheral neuropathy (CIPN) is 15–25% with platinum and taxanes. CIPN can be permanent and often requires dose reduction or change in chemotherapy. Acetyl-l-carnitine (ALCAR), an ester of l-carnitine, is used to treat CIPN in humans and in animal models. The goals of this study are: 1) examine the effects of ALCAR on ovarian cancer cells, 2) determine if ALCAR affects the cytotoxicity of standard chemotherapy on ovarian cancer cells. Methods OVCAR-3 and SKOV-3 ovarian cancer lines were incubated in ALCAR containing media. Viability, proliferation, and expression of the nerve growth factor receptors (NGFR) Trk-A and p-75 were determined by flow cytometry. Cytotoxicity assays examining ALCAR's effect on paclitaxel and carboplatin were done by flow cytometry and infrared plate-reader. Results Flow cytometry showed no change in percent live (p=0.87) or proliferation (p=0.95) of OVCAR-3 cells when comparing controls with up to 100 μM ALCAR. However, there was a slight but significant decrease in the proliferation of SKOV-3 cells incubated at higher ALCAR concentrations (p=<0.01). Flow cytometry showed no difference in the viability of OVCAR-3 cells when comparing ALCAR: +/−paclitaxel (p=1), +/−carboplatin (p=0.8), or both (p=0.4). Proliferation assays indicated that paclitaxel's cytotoxicity on OVCAR-3 and SKOV-3 cells was unchanged at higher ALCAR concentrations (p=<0.01–0.4). ALCAR did not affect the expression of NGFR on OVCAR-3 or SKOV-3 cells. Conclusion ALCAR does not affect the cytotoxicity of paclitaxel or carboplatin. There was no increase in proliferation, or NGFR of OVCAR-3 or SKOV-3 cells exposed to ALCAR." @default.
• W2073636675 created "2016-06-24" @default.
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• W2073636675 date "2009-03-01" @default.
• W2073636675 modified "2023-10-18" @default.
• W2073636675 title "Effect of acetyl-l-carnitine on ovarian cancer cells' proliferation, nerve growth factor receptor (Trk-A and p75) expression, and the cytotoxic potential of paclitaxel and carboplatin" @default.
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• W2073636675 doi "https://doi.org/10.1016/j.ygyno.2008.11.020" @default.
• W2073636675 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3354638" @default.
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