FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073642295> ?p ?o ?g. }

• W2073642295 abstract "The main objective of this investigation was to evaluate the effects of buspirone, a 5-HT(1A) agonist with some partial agonist properties and also an antidepressant, on regional 5-HT synthesis in Flinders Sensitive Line (FSL) rats (depressed), and to compare the effects to the Flinders Resistant Line (FRL) control rats (not depressed). In addition results were compared to those previously reported in normal Sprague-Dawley (SPD) rats (normal control). Serotonin synthesis in both FSL and FRL rats was measured following acute and chronic treatments with buspirone. Both of these strains were derived from the SPD rats. No direct comparison was done between the FSL saline and FRL saline groups, or the FSL buspirone and FRL buspirone groups, because the objective of the studies was to evaluate effects of buspirone in these two strains. The results show that acute treatment with buspirone elevates 5-HT synthesis throughout the brain in the FRL rats. In the FSL rats, there were reductions in some brain regions (e.g., dorsal and median raphe, amygdala, anterior olfactory nucleus, substantia nigra reticulate), while in other regions, there were increases in the synthesis observed (e.g., frontal, parietal, visual and somatosensory cortices, ventral hippocampus). In 20 out of the 30 brain regions investigated in the FSL rats, there was no significant change in the synthesis following acute buspirone treatment. During the chronic treatment, buspirone produced a significant reduction of 5-HT synthesis in 15 out of 30 brain regions in the FRL rats. In the FSL rats, buspirone produced a significant elevation of the synthesis in 10 out of 30 brain regions. In both the FSL and FRL rats, buspirone produced rather different effects than those reported previously for SPD (normal) rats. The acute effect in the FSL rats was somewhat similar to the effect reported previously for the SPD rats, while in the FRL rats, the acute buspirone treatment produced an effect observed previously in treatments with 5-HT(1A) antagonists suggesting an action of buspirone as partial agonist in FRL rats. The data suggest that with respect to 5-HT synthesis, FRL rats differ from SPD rats (a natural control; normal rats) and, as such, indicate that when the effects related to the serotonergic system (e.g., influence of serotonergic drugs) are studied in the FSL rats and compared to those in the FRL rats, any conclusions drawn may not reflect differences relative to a normal rat." @default.
• W2073642295 created "2016-06-24" @default.
• W2073642295 creator A5015931466 @default.
• W2073642295 creator A5017179381 @default.
• W2073642295 creator A5043856028 @default.
• W2073642295 creator A5050696605 @default.
• W2073642295 creator A5083969851 @default.
• W2073642295 date "2009-03-01" @default.
• W2073642295 modified "2023-09-24" @default.
• W2073642295 title "Both acute and chronic buspirone treatments have different effects on regional 5-HT synthesis in Flinders Sensitive Line rats (a rat model of depression) than in control rats" @default.
• W2073642295 cites W1553235867 @default.
• W2073642295 cites W1575948347 @default.
• W2073642295 cites W1661406670 @default.
• W2073642295 cites W1862144680 @default.
• W2073642295 cites W1965651664 @default.
• W2073642295 cites W1967530934 @default.
• W2073642295 cites W1968633470 @default.
• W2073642295 cites W1968901038 @default.
• W2073642295 cites W1968912840 @default.
• W2073642295 cites W1969131430 @default.
• W2073642295 cites W1969422800 @default.
• W2073642295 cites W1972223203 @default.
• W2073642295 cites W1973688077 @default.
• W2073642295 cites W1976132069 @default.
• W2073642295 cites W1976805986 @default.
• W2073642295 cites W1977886627 @default.
• W2073642295 cites W1979873771 @default.
• W2073642295 cites W1979912423 @default.
• W2073642295 cites W1980012680 @default.
• W2073642295 cites W1981515582 @default.
• W2073642295 cites W1981691052 @default.
• W2073642295 cites W1982335931 @default.
• W2073642295 cites W1984659956 @default.
• W2073642295 cites W1985405824 @default.
• W2073642295 cites W1985653700 @default.
• W2073642295 cites W1989168929 @default.
• W2073642295 cites W1993452414 @default.
• W2073642295 cites W1998149725 @default.
• W2073642295 cites W1998168878 @default.
• W2073642295 cites W2002671738 @default.
• W2073642295 cites W2005128569 @default.
• W2073642295 cites W2005145382 @default.
• W2073642295 cites W2006062190 @default.
• W2073642295 cites W2006218562 @default.
• W2073642295 cites W2006449302 @default.
• W2073642295 cites W2012250334 @default.
• W2073642295 cites W2020826809 @default.
• W2073642295 cites W2026001920 @default.
• W2073642295 cites W2029699398 @default.
• W2073642295 cites W2031008625 @default.
• W2073642295 cites W2035630528 @default.
• W2073642295 cites W2038584409 @default.
• W2073642295 cites W2038859823 @default.
• W2073642295 cites W2039391993 @default.
• W2073642295 cites W2040103405 @default.
• W2073642295 cites W2040223618 @default.
• W2073642295 cites W2043219628 @default.
• W2073642295 cites W2045605252 @default.
• W2073642295 cites W2046801007 @default.
• W2073642295 cites W2050087878 @default.
• W2073642295 cites W2052451375 @default.
• W2073642295 cites W2052681595 @default.
• W2073642295 cites W2053472601 @default.
• W2073642295 cites W2055351273 @default.
• W2073642295 cites W2058470067 @default.
• W2073642295 cites W2059368872 @default.
• W2073642295 cites W2060259870 @default.
• W2073642295 cites W2061107253 @default.
• W2073642295 cites W2069715606 @default.
• W2073642295 cites W2070290419 @default.
• W2073642295 cites W2070660174 @default.
• W2073642295 cites W2072630058 @default.
• W2073642295 cites W2076547272 @default.
• W2073642295 cites W2076981513 @default.
• W2073642295 cites W2077755718 @default.
• W2073642295 cites W2089958533 @default.
• W2073642295 cites W2090157452 @default.
• W2073642295 cites W2090252372 @default.
• W2073642295 cites W2094615514 @default.
• W2073642295 cites W2097710542 @default.
• W2073642295 cites W2100700955 @default.
• W2073642295 cites W2120947452 @default.
• W2073642295 cites W2125509251 @default.
• W2073642295 cites W2134389527 @default.
• W2073642295 cites W2134560546 @default.
• W2073642295 cites W2137950391 @default.
• W2073642295 cites W2145926098 @default.
• W2073642295 cites W2147643047 @default.
• W2073642295 cites W2151662898 @default.
• W2073642295 cites W2164389817 @default.
• W2073642295 cites W2165425577 @default.
• W2073642295 cites W2165833361 @default.
• W2073642295 cites W2167677007 @default.
• W2073642295 cites W2170904543 @default.
• W2073642295 cites W2171267699 @default.
• W2073642295 cites W2172245690 @default.
• W2073642295 cites W2313002552 @default.
• W2073642295 cites W2320247467 @default.
• W2073642295 cites W2345595328 @default.
• W2073642295 cites W2396271814 @default.

• next