Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073642667> ?p ?o ?g. }
- W2073642667 endingPage "C153" @default.
- W2073642667 startingPage "C141" @default.
- W2073642667 abstract "Neurotrophin-dependent activation of the tyrosine kinase receptor trkB.FL modulates neuromuscular synapse maintenance and function; however, it is unclear what role the alternative splice variant, truncated trkB (trkB.T1), may have in the peripheral neuromuscular axis. We examined this question in trkB.T1 null mice and demonstrate that in vivo neuromuscular performance and nerve-evoked muscle tension are significantly increased. In vitro assays indicated that the gain-in-function in trkB.T1(-/-) animals resulted specifically from an increased muscle contractility, and increased electrically evoked calcium release. In the trkB.T1 null muscle, we identified an increase in Akt activation in resting muscle as well as a significant increase in trkB.FL and Akt activation in response to contractile activity. On the basis of these findings, we conclude that the trkB signaling pathway might represent a novel target for intervention across diseases characterized by deficits in neuromuscular function." @default.
- W2073642667 created "2016-06-24" @default.
- W2073642667 creator A5000044439 @default.
- W2073642667 creator A5007304865 @default.
- W2073642667 creator A5017948966 @default.
- W2073642667 creator A5019516927 @default.
- W2073642667 creator A5024499528 @default.
- W2073642667 creator A5024836556 @default.
- W2073642667 creator A5026776294 @default.
- W2073642667 creator A5032805931 @default.
- W2073642667 creator A5033136968 @default.
- W2073642667 creator A5033638597 @default.
- W2073642667 creator A5040199904 @default.
- W2073642667 creator A5041736581 @default.
- W2073642667 creator A5041999336 @default.
- W2073642667 creator A5042661935 @default.
- W2073642667 creator A5050080355 @default.
- W2073642667 creator A5058677050 @default.
- W2073642667 creator A5065431323 @default.
- W2073642667 creator A5067810513 @default.
- W2073642667 creator A5076002802 @default.
- W2073642667 creator A5077717253 @default.
- W2073642667 creator A5079376363 @default.
- W2073642667 creator A5083109409 @default.
- W2073642667 creator A5087123403 @default.
- W2073642667 creator A5089966579 @default.
- W2073642667 creator A5091205456 @default.
- W2073642667 date "2012-01-01" @default.
- W2073642667 modified "2023-09-27" @default.
- W2073642667 title "Genetic deletion of trkB.T1 increases neuromuscular function" @default.
- W2073642667 cites W113284015 @default.
- W2073642667 cites W1625740378 @default.
- W2073642667 cites W1892553999 @default.
- W2073642667 cites W1893573483 @default.
- W2073642667 cites W1941910566 @default.
- W2073642667 cites W1965760010 @default.
- W2073642667 cites W1967594973 @default.
- W2073642667 cites W1967635573 @default.
- W2073642667 cites W1968399538 @default.
- W2073642667 cites W1971643720 @default.
- W2073642667 cites W1978774685 @default.
- W2073642667 cites W1985724300 @default.
- W2073642667 cites W1988311308 @default.
- W2073642667 cites W1988524644 @default.
- W2073642667 cites W1990020895 @default.
- W2073642667 cites W1994980684 @default.
- W2073642667 cites W1997428392 @default.
- W2073642667 cites W2009318006 @default.
- W2073642667 cites W2012423618 @default.
- W2073642667 cites W2013648458 @default.
- W2073642667 cites W2015846753 @default.
- W2073642667 cites W2019234059 @default.
- W2073642667 cites W2021497853 @default.
- W2073642667 cites W2027005796 @default.
- W2073642667 cites W2029122808 @default.
- W2073642667 cites W2031053537 @default.
- W2073642667 cites W2031223556 @default.
- W2073642667 cites W2031464795 @default.
- W2073642667 cites W2031811225 @default.
- W2073642667 cites W2036948775 @default.
- W2073642667 cites W2039177386 @default.
- W2073642667 cites W2041796024 @default.
- W2073642667 cites W2047136624 @default.
- W2073642667 cites W2049710193 @default.
- W2073642667 cites W2072768868 @default.
- W2073642667 cites W2073388173 @default.
- W2073642667 cites W2076883884 @default.
- W2073642667 cites W2079055832 @default.
- W2073642667 cites W2081292954 @default.
- W2073642667 cites W2083119172 @default.
- W2073642667 cites W2090459281 @default.
- W2073642667 cites W2093587050 @default.
- W2073642667 cites W2095551553 @default.
- W2073642667 cites W2095754827 @default.
- W2073642667 cites W2106081526 @default.
- W2073642667 cites W2114930258 @default.
- W2073642667 cites W2116556443 @default.
- W2073642667 cites W2117403660 @default.
- W2073642667 cites W2122630126 @default.
- W2073642667 cites W2123343796 @default.
- W2073642667 cites W2125315507 @default.
- W2073642667 cites W2126087211 @default.
- W2073642667 cites W2128960139 @default.
- W2073642667 cites W2129728788 @default.
- W2073642667 cites W2131545168 @default.
- W2073642667 cites W2134141047 @default.
- W2073642667 cites W2136707727 @default.
- W2073642667 cites W2137523402 @default.
- W2073642667 cites W2140533188 @default.
- W2073642667 cites W2141267230 @default.
- W2073642667 cites W2145822569 @default.
- W2073642667 cites W2152252765 @default.
- W2073642667 cites W2154390796 @default.
- W2073642667 cites W2154727263 @default.
- W2073642667 cites W2156015241 @default.
- W2073642667 cites W2157001082 @default.
- W2073642667 cites W2161968092 @default.
- W2073642667 cites W2166601621 @default.