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- W2073642989 abstract "Methylglyoxal-bis(guanylhydrazone) (MGBG) induces a dose-dependent inhibition of the electrophoretic Ca(2+) uptake by rat liver mitochondria (RLM) without affecting the electrical membrane potential. MGBG is also able to inhibit the electroneutral Ca(2+) release from mitochondria. These effects result in a progressive increase of Ca(2+) level in suspending medium indicating that Ca(2+) uptake is inhibited at higher extent than Ca(2+) efflux. Spermine instead, induces a lowering of external Ca(2+) concentration. This action is reversed by MGBG which again raises the external Ca(2+) concentration then in the absence of spermine, though at a lower extent. The mechanism of MGBG effects and their implications on energy metabolism are discussed." @default.
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- W2073642989 date "2002-01-01" @default.
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- W2073642989 title "The effect of methylglyoxal-bis(guanylhydrazone) on mitochondrial Ca2+ fluxes" @default.
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- W2073642989 doi "https://doi.org/10.1016/s0006-2952(01)00827-9" @default.
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