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- W2073645289 abstract "Immunoadsorption onto protein A sepharose can be applied to eliminate immunoglobulins, autoantibodies and circulating immune complexes from the circulation. In vivo kinetic studies showed that all IgG subclasses are removed from the patient's plasma although IgG3 elimination is variable and dependent on the presence of other immunoglobulins. IgG elimination half time was 4.8 days during intermittent and 2.9 days for daily therapy in the absence of immunosuppression. Autoantibodies and immune complexes can be cleared effectively but administration of intravenous immunoglobulins should be avoided because of competition for protein A binding sites. Redistribution/ denovo synthesis (half time 2.1-8.8 d for IgG 1-4) occurred in the absence of immunosuppression." @default.
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- W2073645289 date "1997-12-01" @default.
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- W2073645289 title "Immunoglobulin and Circulating Immune Complex Kinetics During Immunoadsorption onto Protein A Sepharose" @default.
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- W2073645289 doi "https://doi.org/10.1016/s0955-3886(97)00099-4" @default.
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