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- W2073645306 abstract "The mechanisms responsible for protein kinase-c (PKC) mediated potentiation of NMDA receptors are poorly understood. One hypothesis is that PKC-activation reduces the receptor's characteristic voltage-dependent Mg2+-blockade. Experiments performed on Xenopus oocytes expressing cloned NMDA receptors demonstrated that PKC-activation induced no change in the sensitivity of ζlε3 and ζ1ε4 receptors to Mg2+-blockade and, even though PKC-activation did induce a small shift in Mg2+sensitivity for the ζlεl and ζlε2 receptors, the change seen was not large enough to account for an appreciable increase in NMDA receptor activity. Baseline Mg2+-sensitivities and levels of PKC-mediated potentiation were also quantified for each of the di-heteromeric NMDA receptors. The order of Mg2+-sensitivity is ζlε l (most sensitive) > ζlε2 > |solζlg34 > lε3 (least sensitive). PKC-activation caused a 2-fold increase in ζlg4 l currents, a 4-fold increase in 1ε2 currents and no change in either lε3 or lε4 currents. These data suggest that PKC-potentiation of the cloned di-heteromeric NMDA receptors does not involve a reduction in Mg2+-blockade. The di-heteromeric receptors possess varied properties in regard to PKC-potentiation and Mg2+-blockade which have been quantified here." @default.
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- W2073645306 date "1996-01-01" @default.
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- W2073645306 title "Effect of protein kinase-C activation on the Mg2+-sensitivity of cloned NMDA receptors" @default.
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- W2073645306 doi "https://doi.org/10.1016/0028-3908(95)00177-8" @default.
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