FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073647477> ?p ?o ?g. }

• W2073647477 endingPage "e58692" @default.
• W2073647477 startingPage "e58692" @default.
• W2073647477 abstract "Recent evidences have demonstrated that the presence of low pathogenic avian influenza viruses (LPAIV) may play an important role in host ecology and transmission of avian influenza viruses (AIV). While some authors have clearly demonstrated that LPAIV can mutate to render highly pathogenic avian influenza viruses (HPAIV), others have shown that their presence could provide the host with enough immunological memory to resist re-infections with HPAIV. In order to experimentally study the role of pre-existing host immunity, chickens previously infected with H7N2 LPAIV were subsequently challenged with H7N1 HPAIV. Pre-infection of chickens with H7N2 LAPIV conferred protection against the lethal challenge with H7N1 HPAIV, dramatically reducing the viral shedding, the clinical signs and the pathological outcome. Correlating with the protection afforded, sera from chickens primed with H7N2 LPAIV reacted with the H7-AIV subtype in hemagglutination inhibition assay and specifically with the N2-neuraminidase antigen. Conversely, subsequent exposure to H5N1 HPAIV resulted in a two days-delay on the onset of disease but all chickens died by 7 days post-challenge. Lack of protection correlated with the absence of H5-hemagglutining inhibitory antibodies prior to H5N1 HPAIV challenge. Our data suggest that in naturally occurring outbreaks of HPAIV, birds with pre-existing immunity to LPAIV could survive lethal infections with HA-homologous HPAIV but not subsequent re-infections with HA-heterologous HPAIV. These results could be useful to better understand the dynamics of AIV in chickens and might help in future vaccine formulations." @default.
• W2073647477 created "2016-06-24" @default.
• W2073647477 creator A5000374085 @default.
• W2073647477 creator A5012333573 @default.
• W2073647477 creator A5043255174 @default.
• W2073647477 creator A5049114689 @default.
• W2073647477 creator A5050626600 @default.
• W2073647477 creator A5056930329 @default.
• W2073647477 creator A5057417720 @default.
• W2073647477 creator A5067875564 @default.
• W2073647477 creator A5070404913 @default.
• W2073647477 creator A5076664378 @default.
• W2073647477 creator A5079245484 @default.
• W2073647477 creator A5082498438 @default.
• W2073647477 date "2013-03-04" @default.
• W2073647477 modified "2023-10-18" @default.
• W2073647477 title "Exposure to a Low Pathogenic A/H7N2 Virus in Chickens Protects against Highly Pathogenic A/H7N1 Virus but Not against Subsequent Infection with A/H5N1" @default.
• W2073647477 cites W1572838265 @default.
• W2073647477 cites W1858483607 @default.
• W2073647477 cites W1993708257 @default.
• W2073647477 cites W2006893728 @default.
• W2073647477 cites W2015930632 @default.
• W2073647477 cites W2022964359 @default.
• W2073647477 cites W2036413119 @default.
• W2073647477 cites W2041319603 @default.
• W2073647477 cites W2046446387 @default.
• W2073647477 cites W2050076386 @default.
• W2073647477 cites W2050144402 @default.
• W2073647477 cites W2059307069 @default.
• W2073647477 cites W2062786123 @default.
• W2073647477 cites W2069831575 @default.
• W2073647477 cites W2081026750 @default.
• W2073647477 cites W2087142631 @default.
• W2073647477 cites W2091193271 @default.
• W2073647477 cites W2108572774 @default.
• W2073647477 cites W2109564206 @default.
• W2073647477 cites W2110322110 @default.
• W2073647477 cites W2123298285 @default.
• W2073647477 cites W2123446581 @default.
• W2073647477 cites W2137198796 @default.
• W2073647477 cites W2143835164 @default.
• W2073647477 cites W2163006052 @default.
• W2073647477 cites W2168020376 @default.
• W2073647477 doi "https://doi.org/10.1371/journal.pone.0058692" @default.
• W2073647477 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3587606" @default.
• W2073647477 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23469288" @default.
• W2073647477 hasPublicationYear "2013" @default.
• W2073647477 type Work @default.
• W2073647477 sameAs 2073647477 @default.
• W2073647477 citedByCount "8" @default.
• W2073647477 countsByYear W20736474772014 @default.
• W2073647477 countsByYear W20736474772016 @default.
• W2073647477 countsByYear W20736474772018 @default.
• W2073647477 countsByYear W20736474772021 @default.
• W2073647477 crossrefType "journal-article" @default.
• W2073647477 hasAuthorship W2073647477A5000374085 @default.
• W2073647477 hasAuthorship W2073647477A5012333573 @default.
• W2073647477 hasAuthorship W2073647477A5043255174 @default.
• W2073647477 hasAuthorship W2073647477A5049114689 @default.
• W2073647477 hasAuthorship W2073647477A5050626600 @default.
• W2073647477 hasAuthorship W2073647477A5056930329 @default.
• W2073647477 hasAuthorship W2073647477A5057417720 @default.
• W2073647477 hasAuthorship W2073647477A5067875564 @default.
• W2073647477 hasAuthorship W2073647477A5070404913 @default.
• W2073647477 hasAuthorship W2073647477A5076664378 @default.
• W2073647477 hasAuthorship W2073647477A5079245484 @default.
• W2073647477 hasAuthorship W2073647477A5082498438 @default.
• W2073647477 hasBestOaLocation W20736474771 @default.
• W2073647477 hasConcept C104317684 @default.
• W2073647477 hasConcept C116675565 @default.
• W2073647477 hasConcept C126831891 @default.
• W2073647477 hasConcept C12914427 @default.
• W2073647477 hasConcept C134164806 @default.
• W2073647477 hasConcept C159047783 @default.
• W2073647477 hasConcept C203014093 @default.
• W2073647477 hasConcept C2522874641 @default.
• W2073647477 hasConcept C2779341262 @default.
• W2073647477 hasConcept C2780115692 @default.
• W2073647477 hasConcept C3019819676 @default.
• W2073647477 hasConcept C519248777 @default.
• W2073647477 hasConcept C54355233 @default.
• W2073647477 hasConcept C86803240 @default.
• W2073647477 hasConcept C8891405 @default.
• W2073647477 hasConcept C89423630 @default.
• W2073647477 hasConceptScore W2073647477C104317684 @default.
• W2073647477 hasConceptScore W2073647477C116675565 @default.
• W2073647477 hasConceptScore W2073647477C126831891 @default.
• W2073647477 hasConceptScore W2073647477C12914427 @default.
• W2073647477 hasConceptScore W2073647477C134164806 @default.
• W2073647477 hasConceptScore W2073647477C159047783 @default.
• W2073647477 hasConceptScore W2073647477C203014093 @default.
• W2073647477 hasConceptScore W2073647477C2522874641 @default.
• W2073647477 hasConceptScore W2073647477C2779341262 @default.
• W2073647477 hasConceptScore W2073647477C2780115692 @default.
• W2073647477 hasConceptScore W2073647477C3019819676 @default.
• W2073647477 hasConceptScore W2073647477C519248777 @default.
• W2073647477 hasConceptScore W2073647477C54355233 @default.
• W2073647477 hasConceptScore W2073647477C86803240 @default.

• next