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• W2073652257 abstract "ObjectivePrevious retrospective reports have indicated a role of autologous endometrial coculture in the treatment of repeat failure IVF patients. Assessing the merits of different laboratory procedures is notoriously difficult, and to date there have been no prospective randomized trials on the efficacy of autologous endometrial coculture. We have therefore undertaken a retrospective analysis of repeat failure IVF patients (3 or more failures).DesignRetrospective analysisMaterials and methodsPatients who had failed at least three times at IVF treatment elsewhere (n=180) attending for treatment between 1999 and 2003.ResultsThe mean age of the multi failure patients was 36 (±3.9) with a mean of 3.6 (±1.0) failed IVF cycles. The overall pregnancy rate for the multiple failure group was 58%. Overall clinical pregnancy and implantation rates were 44 and 19% respectively. Maternal age had a pronounced effect on cycle outcome with pregnancy rates falling from 69.1% in patients under 35, to 60.5% in patients 35 to 39 years old, and down to 31% in patients 40 and older (P<0.001). Clinical pregnancy rates in these age groups were 60, 54 and 19% (P<0.001). Implantation rates also followed the same pattern being 30, 24 and 7% in the 3 age groups respectively (P<0.001), the mean number of embryos transferred being 3.5, 3.7 and 4.2. By comparison, over the same time period, in first time patients with a mean age of 35, the clinical pregnancy and implantation rates were 63 and 33%, with a mean of 3.1 embryos transferred. These figures comparable favorably with those obtained for patients with repeat IVF failures under 40 years of age.ConclusionImplantation and pregnancy rates are the results of good stimulation and laboratory procedures. This retrospective analysis of repeat failure IVF patients from other programs has shown that it is not necessary to use autologous endometrial co-culture to obtain acceptable pregnancy and implantation rates in such patient groups. Rather, than co-culture, modern laboratory procedures and enhanced cell-free culture systems can be effective in treating repeat failure IVF patients. ObjectivePrevious retrospective reports have indicated a role of autologous endometrial coculture in the treatment of repeat failure IVF patients. Assessing the merits of different laboratory procedures is notoriously difficult, and to date there have been no prospective randomized trials on the efficacy of autologous endometrial coculture. We have therefore undertaken a retrospective analysis of repeat failure IVF patients (3 or more failures). Previous retrospective reports have indicated a role of autologous endometrial coculture in the treatment of repeat failure IVF patients. Assessing the merits of different laboratory procedures is notoriously difficult, and to date there have been no prospective randomized trials on the efficacy of autologous endometrial coculture. We have therefore undertaken a retrospective analysis of repeat failure IVF patients (3 or more failures). DesignRetrospective analysis Retrospective analysis Materials and methodsPatients who had failed at least three times at IVF treatment elsewhere (n=180) attending for treatment between 1999 and 2003. Patients who had failed at least three times at IVF treatment elsewhere (n=180) attending for treatment between 1999 and 2003. ResultsThe mean age of the multi failure patients was 36 (±3.9) with a mean of 3.6 (±1.0) failed IVF cycles. The overall pregnancy rate for the multiple failure group was 58%. Overall clinical pregnancy and implantation rates were 44 and 19% respectively. Maternal age had a pronounced effect on cycle outcome with pregnancy rates falling from 69.1% in patients under 35, to 60.5% in patients 35 to 39 years old, and down to 31% in patients 40 and older (P<0.001). Clinical pregnancy rates in these age groups were 60, 54 and 19% (P<0.001). Implantation rates also followed the same pattern being 30, 24 and 7% in the 3 age groups respectively (P<0.001), the mean number of embryos transferred being 3.5, 3.7 and 4.2. By comparison, over the same time period, in first time patients with a mean age of 35, the clinical pregnancy and implantation rates were 63 and 33%, with a mean of 3.1 embryos transferred. These figures comparable favorably with those obtained for patients with repeat IVF failures under 40 years of age. The mean age of the multi failure patients was 36 (±3.9) with a mean of 3.6 (±1.0) failed IVF cycles. The overall pregnancy rate for the multiple failure group was 58%. Overall clinical pregnancy and implantation rates were 44 and 19% respectively. Maternal age had a pronounced effect on cycle outcome with pregnancy rates falling from 69.1% in patients under 35, to 60.5% in patients 35 to 39 years old, and down to 31% in patients 40 and older (P<0.001). Clinical pregnancy rates in these age groups were 60, 54 and 19% (P<0.001). Implantation rates also followed the same pattern being 30, 24 and 7% in the 3 age groups respectively (P<0.001), the mean number of embryos transferred being 3.5, 3.7 and 4.2. By comparison, over the same time period, in first time patients with a mean age of 35, the clinical pregnancy and implantation rates were 63 and 33%, with a mean of 3.1 embryos transferred. These figures comparable favorably with those obtained for patients with repeat IVF failures under 40 years of age. ConclusionImplantation and pregnancy rates are the results of good stimulation and laboratory procedures. This retrospective analysis of repeat failure IVF patients from other programs has shown that it is not necessary to use autologous endometrial co-culture to obtain acceptable pregnancy and implantation rates in such patient groups. Rather, than co-culture, modern laboratory procedures and enhanced cell-free culture systems can be effective in treating repeat failure IVF patients. Implantation and pregnancy rates are the results of good stimulation and laboratory procedures. This retrospective analysis of repeat failure IVF patients from other programs has shown that it is not necessary to use autologous endometrial co-culture to obtain acceptable pregnancy and implantation rates in such patient groups. Rather, than co-culture, modern laboratory procedures and enhanced cell-free culture systems can be effective in treating repeat failure IVF patients." @default.
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• W2073652257 date "2004-09-01" @default.
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• W2073652257 title "Treatment of multiple failed IVF attempts: Is endometrial coculture necessary?" @default.
• W2073652257 doi "https://doi.org/10.1016/j.fertnstert.2004.07.505" @default.
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