Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073656988> ?p ?o ?g. }
- W2073656988 endingPage "182" @default.
- W2073656988 startingPage "170" @default.
- W2073656988 abstract "Astrocytes are fundamental for homoeostasis, defence and regeneration of the central nervous system. Loss of astroglial function and astroglial reactivity contributes to the aging of the brain and to neurodegenerative diseases. Changes in astroglia in aging and neurodegeneration are highly heterogeneous and region-specific. In animal models of Alzheimer's disease (AD) astrocytes undergo degeneration and atrophy at the early stages of pathological progression, which possibly may alter the homeostatic reserve of the brain and contribute to early cognitive deficits. At later stages of AD reactive astrocytes are associated with neurite plaques, the feature commonly found in animal models and in human diseased tissue. In animal models of the AD reactive astrogliosis develops in some (e.g. in the hippocampus) but not in all regions of the brain. For instance, in entorhinal and prefrontal cortices astrocytes do not mount gliotic response to emerging β-amyloid deposits. These deficits in reactivity coincide with higher vulnerability of these regions to AD-type pathology. Astroglial morphology and function can be regulated through environmental stimulation and/or medication suggesting that astrocytes can be regarded as a target for therapies aimed at the prevention and cure of neurodegenerative disorders." @default.
- W2073656988 created "2016-06-24" @default.
- W2073656988 creator A5016152202 @default.
- W2073656988 creator A5025932270 @default.
- W2073656988 creator A5065962331 @default.
- W2073656988 creator A5083227570 @default.
- W2073656988 date "2016-05-01" @default.
- W2073656988 modified "2023-10-15" @default.
- W2073656988 title "Astrocytes in physiological aging and Alzheimer’s disease" @default.
- W2073656988 cites W1511356115 @default.
- W2073656988 cites W1521796967 @default.
- W2073656988 cites W1523042311 @default.
- W2073656988 cites W1549972124 @default.
- W2073656988 cites W156249982 @default.
- W2073656988 cites W1584825376 @default.
- W2073656988 cites W1762188861 @default.
- W2073656988 cites W1819282061 @default.
- W2073656988 cites W1832520743 @default.
- W2073656988 cites W1884999644 @default.
- W2073656988 cites W1953584638 @default.
- W2073656988 cites W1967464880 @default.
- W2073656988 cites W1967794260 @default.
- W2073656988 cites W1968652796 @default.
- W2073656988 cites W1970820517 @default.
- W2073656988 cites W1974294728 @default.
- W2073656988 cites W1975478767 @default.
- W2073656988 cites W1976444375 @default.
- W2073656988 cites W1977002082 @default.
- W2073656988 cites W1978453599 @default.
- W2073656988 cites W1985692753 @default.
- W2073656988 cites W1989065264 @default.
- W2073656988 cites W1992758695 @default.
- W2073656988 cites W1994640389 @default.
- W2073656988 cites W1996347415 @default.
- W2073656988 cites W1996996429 @default.
- W2073656988 cites W1998338131 @default.
- W2073656988 cites W2000075190 @default.
- W2073656988 cites W2002970043 @default.
- W2073656988 cites W2007664874 @default.
- W2073656988 cites W2007814938 @default.
- W2073656988 cites W2009065017 @default.
- W2073656988 cites W2010217187 @default.
- W2073656988 cites W2010476270 @default.
- W2073656988 cites W2010683624 @default.
- W2073656988 cites W2012601853 @default.
- W2073656988 cites W2015387012 @default.
- W2073656988 cites W2015607124 @default.
- W2073656988 cites W2018813802 @default.
- W2073656988 cites W2019970707 @default.
- W2073656988 cites W2022127378 @default.
- W2073656988 cites W2022649067 @default.
- W2073656988 cites W2026211597 @default.
- W2073656988 cites W2027616725 @default.
- W2073656988 cites W2029227072 @default.
- W2073656988 cites W2029525783 @default.
- W2073656988 cites W2031155126 @default.
- W2073656988 cites W2034888816 @default.
- W2073656988 cites W2035351488 @default.
- W2073656988 cites W2035416600 @default.
- W2073656988 cites W2035839706 @default.
- W2073656988 cites W2037811130 @default.
- W2073656988 cites W2037904566 @default.
- W2073656988 cites W2044219916 @default.
- W2073656988 cites W2047036396 @default.
- W2073656988 cites W2047417026 @default.
- W2073656988 cites W2047556028 @default.
- W2073656988 cites W2047585900 @default.
- W2073656988 cites W2050048961 @default.
- W2073656988 cites W2055180596 @default.
- W2073656988 cites W2057217107 @default.
- W2073656988 cites W2058495283 @default.
- W2073656988 cites W2059150405 @default.
- W2073656988 cites W2063891183 @default.
- W2073656988 cites W2064119008 @default.
- W2073656988 cites W2068334330 @default.
- W2073656988 cites W2069544569 @default.
- W2073656988 cites W2069888362 @default.
- W2073656988 cites W2069889593 @default.
- W2073656988 cites W2071695496 @default.
- W2073656988 cites W2072210142 @default.
- W2073656988 cites W2076316745 @default.
- W2073656988 cites W2081726573 @default.
- W2073656988 cites W2084792449 @default.
- W2073656988 cites W2085262263 @default.
- W2073656988 cites W2085424855 @default.
- W2073656988 cites W2086400668 @default.
- W2073656988 cites W2088318073 @default.
- W2073656988 cites W2089581014 @default.
- W2073656988 cites W2089715790 @default.
- W2073656988 cites W2092276546 @default.
- W2073656988 cites W2094380024 @default.
- W2073656988 cites W2094805317 @default.
- W2073656988 cites W2095454332 @default.
- W2073656988 cites W2098190939 @default.
- W2073656988 cites W2100314515 @default.
- W2073656988 cites W2106729121 @default.
- W2073656988 cites W2106902340 @default.
- W2073656988 cites W2107376426 @default.