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• W2073657338 abstract "An in vivo assay for BCG anti-cancer efficacy was developed, utilizing subcutaneous injection into CFW Swiss-Webster mice of cultured S180 sarcoma cells and mixed with freeze-dried TiceTM BCG vaccine. A BCG dose of 0.156-1.56 mg dry weight significantly inhibited tumor formation, but a BCG dose of 0.156-1.56 micrograms significantly enhanced tumor growth, evidenced by increased tumor incidence, volume and initial growth rate. These antagonistic activities may contribute to the high variability of BCG anti-cancer efficacy seen in animals and humans and indicate the need to exercise caution when employing even low doses of BCG for cancer immunotherapy." @default.
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• W2073657338 date "1991-02-01" @default.
• W2073657338 modified "2023-09-26" @default.
• W2073657338 title "High-dose inhibition and low-dose enhancement of murine sarcoma growth exhibited by BCG vaccine" @default.
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• W2073657338 doi "https://doi.org/10.1016/0304-3835(91)90088-y" @default.
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