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- W2073663800 abstract "Cleavage of 4-pyrrole phenylacyl TentaGel-appended peptide (5) containing Arg(Pbf) with trifluoroacetic acid/triisopropylsilane/phenol/H2O (90/2/4/4) gives the 4-pyrrole phenylacyl peptide (3). However, cleavage of 4-pyrrole phenylacyl Rink-appended peptide (7) containing Arg(Pbf) using the same reagents furnishes the 4-pyrrolidine phenylacyl peptide (8), which contains the reduced pyrrole ring. Compound 8 displays a Ki of 2.32 microM, approximately fivefold less potent than compound 3." @default.
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- W2073663800 date "2005-05-01" @default.
- W2073663800 modified "2023-09-27" @default.
- W2073663800 title "Reduction of a 4-pyrrole phenylacyl-containing peptide with trifluoroacetic acid–triisopropylsilane–phenol–H2O during solid-phase peptide synthesis and its protein kinase C α inhibitory activity" @default.
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- W2073663800 doi "https://doi.org/10.1016/j.bmcl.2005.03.006" @default.
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