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• W2073668327 abstract "Abstract In acute experiments in rats anesthetized with urethane, the field potentials, population spike, and unit activity evoked in the hypothalamic ventromedial nucleus (HVM) by amygdaloid stimulation are significantly increased with respect to control when preceded by a conditioning volley at 20- to 100-ms intervals. Under pentobarbital anesthesia, in contrast, the evoked responses were inhibited by the conditioning stimulus for similar interstimulus intervals. In unanesthetized animals chronically implanted with stimulating and recording electrodes, a facilitation of responses by a conditioning stimulus was observed when they were awake or anesthetized with urethane. When the same animals were anesthetized with pentobarbital the HVM evoked response was inhibited by a conditioning pulse. Frequency facilitation and post-tetanic potentiation of HVM responses were markedly enhanced under urethane, whereas in pentobarbital-anesthetized animals inhibition predominated. Picrotoxin reversed the inhibition under pentobarbital to facilitation. These results suggest that the HVM neuron population is under both excitatory and inhibitory influences from the amygdala, the former being predominant in awake and urethane-anesthetized animals and the latter being expressed under pentobarbital anesthesia and is probably mediated by γ-aminobutyric acid." @default.
• W2073668327 created "2016-06-24" @default.
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• W2073668327 date "1980-03-01" @default.
• W2073668327 modified "2023-09-26" @default.
• W2073668327 title "Anesthetic-dependent excitability changes in the hypothalamic ventromedial nucleus of the rat" @default.
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• W2073668327 doi "https://doi.org/10.1016/0014-4886(80)90124-7" @default.
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