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• W2073670822 startingPage "114" @default.
• W2073670822 abstract "As part of a drug delivery project, four aldehydes of the type Pam-Lys(Pam)-spacer-CO-CHO were synthesized to be included in targeting colloids. Though amphiphilic, they were obtained within reasonable yields (18–55%) and with high RP-HPLC purity (∼90%). Parallely, six complementary targeting peptides of the type H2N-NH-CH2-CO-spacer-YGRGDSP-NH2 were prepared to be anchored onto colloids. Isolated yields are related to the spacer length and nature. To easily and rapidly modulate the distance between the peptide and the vesicle, every partners were elaborated on solid phase and the expected constructions were obtained by hydrazone ligation. One possible application is presented here with multilamellar vesicles targeting HUVEC cells. Preliminary results prove that the fine-tuning of the spacer length permits to optimize the recognition toward the target cells." @default.
• W2073670822 created "2016-06-24" @default.
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• W2073670822 date "2007-01-01" @default.
• W2073670822 modified "2023-10-18" @default.
• W2073670822 title "Synthesis of versatile chemical tools toward a structure/properties relationships study onto targeting colloids" @default.
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• W2073670822 doi "https://doi.org/10.1016/j.ejmech.2006.08.011" @default.
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