FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073671027> ?p ?o ?g. }

• W2073671027 endingPage "3988" @default.
• W2073671027 startingPage "3970" @default.
• W2073671027 abstract "The antioxidative properties of a novel curcumin analogue (2E,6E)-2,6-bis(3,5-dimethoxybenzylidene)cyclohexanone (MCH) were assessed by several in vitro models, including superoxide anion, hydroxyl radical and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and PC12 cell protection from H2O2 damage. MCH displayed superior O2•− quenching abilities compared to curcumin and vitamin C. In vitro stability of MCH was also improved compared with curcumin. Exposure of PC12 cells to 150 µM H2O2 caused a decrease of antioxidant enzyme activities, glutathione (GSH) loss, an increase in malondialdehyde (MDA) level, and leakage of lactate dehydrogenase (LDH), cell apoptosis and reduction in cell viability. Pretreatment of the cells with MCH at 0.63–5.00 µM before H2O2 exposure significantly attenuated those changes in a dose-dependent manner. MCH enhanced cellular expression of transcription factor NF-E2-related factor 2 (Nrf2) at the transcriptional level. Moreover, MCH could mitigate intracellular accumulation of reactive oxygen species (ROS), the loss of mitochondrial membrane potential (MMP), and the increase of cleaved caspase-3 activity induced by H2O2. These results show that MCH protects PC12 cells from H2O2 injury by modulating endogenous antioxidant enzymes, scavenging ROS, activating the Nrf2 cytoprotective pathway and prevention of apoptosis." @default.
• W2073671027 created "2016-06-24" @default.
• W2073671027 creator A5006099458 @default.
• W2073671027 creator A5029594423 @default.
• W2073671027 creator A5065531732 @default.
• W2073671027 creator A5069214524 @default.
• W2073671027 date "2014-03-05" @default.
• W2073671027 modified "2023-09-23" @default.
• W2073671027 title "Antioxidant Properties and PC12 Cell Protective Effects of a Novel Curcumin Analogue (2E,6E)-2,6-Bis(3,5- dimethoxybenzylidene)cyclohexanone (MCH)" @default.
• W2073671027 cites W1558835554 @default.
• W2073671027 cites W1910761843 @default.
• W2073671027 cites W1967886692 @default.
• W2073671027 cites W1972179974 @default.
• W2073671027 cites W1976194786 @default.
• W2073671027 cites W1977319429 @default.
• W2073671027 cites W1978152747 @default.
• W2073671027 cites W1978206619 @default.
• W2073671027 cites W1991197498 @default.
• W2073671027 cites W1995043836 @default.
• W2073671027 cites W1996370639 @default.
• W2073671027 cites W2001098151 @default.
• W2073671027 cites W2002408632 @default.
• W2073671027 cites W2004598818 @default.
• W2073671027 cites W2011243629 @default.
• W2073671027 cites W2014999693 @default.
• W2073671027 cites W2021269411 @default.
• W2073671027 cites W2029816748 @default.
• W2073671027 cites W2037222034 @default.
• W2073671027 cites W2038518301 @default.
• W2073671027 cites W2058780002 @default.
• W2073671027 cites W2060713730 @default.
• W2073671027 cites W2063879938 @default.
• W2073671027 cites W2070285465 @default.
• W2073671027 cites W2072175441 @default.
• W2073671027 cites W2076935230 @default.
• W2073671027 cites W2093810351 @default.
• W2073671027 cites W2101108802 @default.
• W2073671027 cites W2114744780 @default.
• W2073671027 cites W2125598794 @default.
• W2073671027 cites W2126600948 @default.
• W2073671027 cites W2132826785 @default.
• W2073671027 cites W2148125367 @default.
• W2073671027 cites W2157067671 @default.
• W2073671027 cites W2159768584 @default.
• W2073671027 cites W2165529854 @default.
• W2073671027 cites W2313491323 @default.
• W2073671027 cites W4293247451 @default.
• W2073671027 doi "https://doi.org/10.3390/ijms15033970" @default.
• W2073671027 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3975378" @default.
• W2073671027 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24603537" @default.
• W2073671027 hasPublicationYear "2014" @default.
• W2073671027 type Work @default.
• W2073671027 sameAs 2073671027 @default.
• W2073671027 citedByCount "15" @default.
• W2073671027 countsByYear W20736710272014 @default.
• W2073671027 countsByYear W20736710272015 @default.
• W2073671027 countsByYear W20736710272016 @default.
• W2073671027 countsByYear W20736710272017 @default.
• W2073671027 countsByYear W20736710272018 @default.
• W2073671027 countsByYear W20736710272019 @default.
• W2073671027 countsByYear W20736710272020 @default.
• W2073671027 countsByYear W20736710272021 @default.
• W2073671027 crossrefType "journal-article" @default.
• W2073671027 hasAuthorship W2073671027A5006099458 @default.
• W2073671027 hasAuthorship W2073671027A5029594423 @default.
• W2073671027 hasAuthorship W2073671027A5065531732 @default.
• W2073671027 hasAuthorship W2073671027A5069214524 @default.
• W2073671027 hasBestOaLocation W20736710271 @default.
• W2073671027 hasConcept C181199279 @default.
• W2073671027 hasConcept C185592680 @default.
• W2073671027 hasConcept C190283241 @default.
• W2073671027 hasConcept C2776778087 @default.
• W2073671027 hasConcept C2777318727 @default.
• W2073671027 hasConcept C2778004101 @default.
• W2073671027 hasConcept C2778250585 @default.
• W2073671027 hasConcept C2778401633 @default.
• W2073671027 hasConcept C2780795997 @default.
• W2073671027 hasConcept C2781401929 @default.
• W2073671027 hasConcept C48349386 @default.
• W2073671027 hasConcept C53227056 @default.
• W2073671027 hasConcept C538909803 @default.
• W2073671027 hasConcept C55493867 @default.
• W2073671027 hasConcept C79879829 @default.
• W2073671027 hasConcept C86803240 @default.
• W2073671027 hasConcept C98274493 @default.
• W2073671027 hasConceptScore W2073671027C181199279 @default.
• W2073671027 hasConceptScore W2073671027C185592680 @default.
• W2073671027 hasConceptScore W2073671027C190283241 @default.
• W2073671027 hasConceptScore W2073671027C2776778087 @default.
• W2073671027 hasConceptScore W2073671027C2777318727 @default.
• W2073671027 hasConceptScore W2073671027C2778004101 @default.
• W2073671027 hasConceptScore W2073671027C2778250585 @default.
• W2073671027 hasConceptScore W2073671027C2778401633 @default.
• W2073671027 hasConceptScore W2073671027C2780795997 @default.
• W2073671027 hasConceptScore W2073671027C2781401929 @default.
• W2073671027 hasConceptScore W2073671027C48349386 @default.
• W2073671027 hasConceptScore W2073671027C53227056 @default.
• W2073671027 hasConceptScore W2073671027C538909803 @default.

• next