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• W2073676006 abstract "Flavonolignan silybin (1) present in the seeds of the milk thistle (Silybum marianum) is widely used in human therapy of liver dysfunctions and as a hepatoprotectant thanks to its dual function: it acts as a highly effective radical scavenger (antilipoperoxidant) and also as an antioxidant. Molecular mechanisms of antiradical action of 1 and even functional groups responsible for this activity are not well known so far. Silybin forms during in vitro reaction with stable radicals (e.g., DPPH) or with enzyme laccase (Trametes pubescens) complex mixtures of oligomeric and polymeric products whose structural analysis is virtually impossible. Methylation of 7-OH in 1 yields under laccase-mediated oxidation C–O and C–C dimers in the ratio ca. 1:2.5. Using this approach, the hydroxyl groups responsible for antiradical activity of silybin (20-OH group) were determined and the molecular mechanism of the E-ring antiradical activity was explained." @default.
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• W2073676006 date "2008-02-01" @default.
• W2073676006 modified "2023-10-17" @default.
• W2073676006 title "Laccase-mediated dimerization of the flavonolignan silybin" @default.
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• W2073676006 doi "https://doi.org/10.1016/j.molcatb.2007.09.005" @default.
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