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- W2073677126 abstract "It is well accepted, that a HPLC-MS/MS assay can outperform immunoassays in therapeutic drug monitoring (TDM) due to its increased accuracy, sensitivity, and precision. However, the occurrence of sudden and unpredictable ion yield attenuation, can hamper assay performance. Such “ion suppression effects” are considered a central analytical problem if using an MS/MS detector in bio-analysis. Since pathological patient specimen compositions or individual co-medications may be major causes for ion yield fluctuations, measures have to be taken to evaluate these interferences prior to transferring an HPLC-MS/MS assay to routine use." @default.
- W2073677126 created "2016-06-24" @default.
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- W2073677126 date "2009-01-01" @default.
- W2073677126 modified "2023-10-01" @default.
- W2073677126 title "How to Deal with Ion Suppression – the Foe of HPLC-MS/MS" @default.
- W2073677126 doi "https://doi.org/10.3797/scipharm.oephg.21.sl-03" @default.
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