FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073677221> ?p ?o ?g. }

• W2073677221 endingPage "1276" @default.
• W2073677221 startingPage "1267" @default.
• W2073677221 abstract "Natural killer T (NKT) cells and regulatory T cells (Tregs) are both found within the liver and are known to exhibit immune regulatory functions. Hepatic NKT cells are activated early during inflammatory responses and release cytokines, including interferon gamma (IFN-γ), which we speculated could regulate Treg recruitment to the liver. To examine this, we treated C57BL/6 mice with a specific NKT cell activating ligand α galactosyl-C18-ceramide (αGal-C18-Cer) and examined the hepatic recruitment of Tregs. We found a time-dependant increase in the hepatic recruitment of Tregs after NKT cell activation, which was absent in NKT cell–deficient mice. Most recruited Tregs expressed interleukin (IL) 10, and to a lesser extent transforming growth factor beta (TGF-β). Because IFN-γ induces the production of chemokine (C-X-C motif) ligand 10 (CXCL10), and Tregs can express the cognate receptor for CXCL10 (that is, CXCR3), we considered that CXCL10 might mediate the hepatic recruitment of Tregs after NKT cell activation. Hepatic CXCL10 levels were markedly increased after αGal-C18-Cer administration in wild-type but not in NKT cell–deficient mice. Moreover, approximately 50% of Tregs recruited to the liver after αGal-C18-Cer administration expressed CXCR3 and CXCR3+ Treg recruitment into the liver was significantly inhibited in IFN-γ KO mice, and after CXCL10 neutralization. In addition, prevention of CXCR3+ Treg recruitment into the liver enhanced inflammatory effector cell recruitment into the liver after αGal-C18-Cer treatment. Conclusion: These results show that activated NKT cells can induce the hepatic recruitment of Tregs through a cytokine-to-chemokine pathway, which could be relevant in the development of chemokine blocking or NKT cell activating strategies to treat liver diseases. (HEPATOLOGY 2009.)" @default.
• W2073677221 created "2016-06-24" @default.
• W2073677221 creator A5012538066 @default.
• W2073677221 creator A5022281664 @default.
• W2073677221 creator A5049692788 @default.
• W2073677221 creator A5074351368 @default.
• W2073677221 creator A5083971802 @default.
• W2073677221 date "2008-12-02" @default.
• W2073677221 modified "2023-10-17" @default.
• W2073677221 title "Natural killer T cells regulate the homing of chemokine CXC receptor 3-positive regulatory T cells to the liver in mice" @default.
• W2073677221 cites W1488156742 @default.
• W2073677221 cites W1501511128 @default.
• W2073677221 cites W1518082296 @default.
• W2073677221 cites W1585751203 @default.
• W2073677221 cites W1653749361 @default.
• W2073677221 cites W1659107174 @default.
• W2073677221 cites W1921895749 @default.
• W2073677221 cites W1973581853 @default.
• W2073677221 cites W1986337007 @default.
• W2073677221 cites W2003747312 @default.
• W2073677221 cites W2004708987 @default.
• W2073677221 cites W2005249381 @default.
• W2073677221 cites W2011319298 @default.
• W2073677221 cites W2019623482 @default.
• W2073677221 cites W2031061214 @default.
• W2073677221 cites W2036117709 @default.
• W2073677221 cites W2040303258 @default.
• W2073677221 cites W2045631856 @default.
• W2073677221 cites W2048568752 @default.
• W2073677221 cites W2049059614 @default.
• W2073677221 cites W2053261820 @default.
• W2073677221 cites W2061631515 @default.
• W2073677221 cites W2063001043 @default.
• W2073677221 cites W2080891404 @default.
• W2073677221 cites W2087287657 @default.
• W2073677221 cites W2089840168 @default.
• W2073677221 cites W2096819313 @default.
• W2073677221 cites W2097863119 @default.
• W2073677221 cites W2099088088 @default.
• W2073677221 cites W2116813965 @default.
• W2073677221 cites W2121477549 @default.
• W2073677221 cites W2122472377 @default.
• W2073677221 cites W2128705210 @default.
• W2073677221 cites W2130858592 @default.
• W2073677221 cites W2131778873 @default.
• W2073677221 cites W2143880475 @default.
• W2073677221 cites W2148806075 @default.
• W2073677221 cites W2151164793 @default.
• W2073677221 cites W2151513687 @default.
• W2073677221 cites W2152644554 @default.
• W2073677221 cites W2161307276 @default.
• W2073677221 cites W2162666968 @default.
• W2073677221 cites W2165575329 @default.
• W2073677221 doi "https://doi.org/10.1002/hep.22761" @default.
• W2073677221 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19140218" @default.
• W2073677221 hasPublicationYear "2008" @default.
• W2073677221 type Work @default.
• W2073677221 sameAs 2073677221 @default.
• W2073677221 citedByCount "79" @default.
• W2073677221 countsByYear W20736772212012 @default.
• W2073677221 countsByYear W20736772212013 @default.
• W2073677221 countsByYear W20736772212014 @default.
• W2073677221 countsByYear W20736772212015 @default.
• W2073677221 countsByYear W20736772212016 @default.
• W2073677221 countsByYear W20736772212017 @default.
• W2073677221 countsByYear W20736772212018 @default.
• W2073677221 countsByYear W20736772212019 @default.
• W2073677221 countsByYear W20736772212020 @default.
• W2073677221 countsByYear W20736772212021 @default.
• W2073677221 countsByYear W20736772212022 @default.
• W2073677221 countsByYear W20736772212023 @default.
• W2073677221 crossrefType "journal-article" @default.
• W2073677221 hasAuthorship W2073677221A5012538066 @default.
• W2073677221 hasAuthorship W2073677221A5022281664 @default.
• W2073677221 hasAuthorship W2073677221A5049692788 @default.
• W2073677221 hasAuthorship W2073677221A5074351368 @default.
• W2073677221 hasAuthorship W2073677221A5083971802 @default.
• W2073677221 hasBestOaLocation W20736772211 @default.
• W2073677221 hasConcept C12823836 @default.
• W2073677221 hasConcept C13373296 @default.
• W2073677221 hasConcept C139563560 @default.
• W2073677221 hasConcept C17502307 @default.
• W2073677221 hasConcept C203014093 @default.
• W2073677221 hasConcept C25532541 @default.
• W2073677221 hasConcept C2776090121 @default.
• W2073677221 hasConcept C2778690821 @default.
• W2073677221 hasConcept C5858377 @default.
• W2073677221 hasConcept C86803240 @default.
• W2073677221 hasConcept C8891405 @default.
• W2073677221 hasConceptScore W2073677221C12823836 @default.
• W2073677221 hasConceptScore W2073677221C13373296 @default.
• W2073677221 hasConceptScore W2073677221C139563560 @default.
• W2073677221 hasConceptScore W2073677221C17502307 @default.
• W2073677221 hasConceptScore W2073677221C203014093 @default.
• W2073677221 hasConceptScore W2073677221C25532541 @default.
• W2073677221 hasConceptScore W2073677221C2776090121 @default.
• W2073677221 hasConceptScore W2073677221C2778690821 @default.
• W2073677221 hasConceptScore W2073677221C5858377 @default.

• next