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• W2073681661 abstract "We developed a computational model of lung parenchyma, which is comprised of individual alveolar chamber models. Each alveolus is modeled by a truncated octahedron. Considering the force balance between the elastin and collagen fibers laying on the alveolar membrane and the pressures acting on the membrane, we computed the deformations of the parenchyma with a finite element method. We focused on the effect of surfactant on the force of parenchymal tethering an airway. As the lung inflates, the parenchyma becomes stiffer and the tethering force becomes stronger. As the alveolar surfactant concentration is reduced, the lung volume at a fixed alveolar pressure decreases, and thus, the tethering force becomes weaker. The distortion of parenchyma caused by the deformation of an airway extends widely around the airway. The displacement of parenchyma decays with distance from the airway wall, but deviates from the prediction based on a theory for a continuum material. Using results obtained from the present lung parenchyma model, we also developed a simple 1-dimensional model for parenchyma tethering force on an airway, which could be utilized for the analysis of liquid/gas transports in an axis-symmetric elastic airway. The effective shear modulus was calculated from the pressure–volume relation of parenchyma. By manipulating the pressure–volume curve, this simple model may be used to predict the parenchyma tethering force in diseased lungs." @default.
• W2073681661 created "2016-06-24" @default.
• W2073681661 creator A5011521796 @default.
• W2073681661 creator A5079007417 @default.
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• W2073681661 date "2013-01-01" @default.
• W2073681661 modified "2023-10-15" @default.
• W2073681661 title "A model of surfactant-induced surface tension effects on the parenchymal tethering of pulmonary airways" @default.
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• W2073681661 doi "https://doi.org/10.1016/j.jbiomech.2012.11.031" @default.
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• W2073681661 hasPublicationYear "2013" @default.
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