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- W2073683673 abstract "Evolutionary relationships between neuroendocrine peptides are often difficult to resolve across divergent phyla due to independent duplication events in different lineages. Thanks to peptide purification and molecular cloning in many different species, the situation is beginning to clear for the neuropeptide Y (NPY) family, which also includes peptide YY (PYY), the tetrapod pancreatic polypeptide (PP) and the fish pancreatic peptide Y (PY). It has long been assumed that the first duplication to occur in vertebrate evolution generated NPY and PYY, as both of these are found in all gnathostomes as well as lamprey. Evidence from other gene families show that this duplication was probably a chromosome duplication event. The origin of a second PYY peptide found in lamprey remains to be explained. Our recent cloning of NPY, PYY and PY in the sea bass proves that fish PY is a separate gene product. We favour the hypothesis that PY is a duplicate of the PYY gene and that it may have occurred late in fish evolution, as PY has so far only been found in acanthomorph fishes. Thus, this duplication seems to be independent of the one that generate PP from PYY in tetrapods, although both tetrapod PP and fish PY are expressed in the pancreas. Studies in the sea bass and other fish show that PY, in contrast to PP, is expressed in the nervous system. We review the literature on the distribution and functional aspects of the various NPY-family peptides in vertebrates. Key words: neuropeptide Y, pancreatic polypeptide, fish pancreatic peptide, gene duplication." @default.
- W2073683673 created "2016-06-24" @default.
- W2073683673 creator A5014642344 @default.
- W2073683673 creator A5061245649 @default.
- W2073683673 date "2000-04-02" @default.
- W2073683673 modified "2023-10-10" @default.
- W2073683673 title "Neuropeptide Y family of peptides: Structure, anatomical expression, function, and molecular evolution" @default.
- W2073683673 cites W1482242717 @default.
- W2073683673 cites W1497005073 @default.
- W2073683673 cites W1499341760 @default.
- W2073683673 cites W1500786177 @default.
- W2073683673 cites W1505089585 @default.
- W2073683673 cites W1517820583 @default.
- W2073683673 cites W1535097151 @default.
- W2073683673 cites W1544678046 @default.
- W2073683673 cites W1562035843 @default.
- W2073683673 cites W1577644682 @default.
- W2073683673 cites W1595497744 @default.
- W2073683673 cites W1596404156 @default.
- W2073683673 cites W1963541671 @default.
- W2073683673 cites W1964954360 @default.
- W2073683673 cites W1965149518 @default.
- W2073683673 cites W1967901105 @default.
- W2073683673 cites W1968680649 @default.
- W2073683673 cites W1968972378 @default.
- W2073683673 cites W1970107543 @default.
- W2073683673 cites W1971059053 @default.
- W2073683673 cites W1971250912 @default.
- W2073683673 cites W1972422736 @default.
- W2073683673 cites W1972908934 @default.
- W2073683673 cites W1976640392 @default.
- W2073683673 cites W1977784637 @default.
- W2073683673 cites W1979579188 @default.
- W2073683673 cites W1980173412 @default.
- W2073683673 cites W1984519863 @default.
- W2073683673 cites W1987306390 @default.
- W2073683673 cites W1989087522 @default.
- W2073683673 cites W1990802307 @default.
- W2073683673 cites W1991216500 @default.
- W2073683673 cites W1992084581 @default.
- W2073683673 cites W1994546189 @default.
- W2073683673 cites W1996534061 @default.
- W2073683673 cites W1997060814 @default.
- W2073683673 cites W1997346770 @default.
- W2073683673 cites W1997653830 @default.
- W2073683673 cites W1998287752 @default.
- W2073683673 cites W1998372148 @default.
- W2073683673 cites W1999631481 @default.
- W2073683673 cites W1999866365 @default.
- W2073683673 cites W2001660140 @default.
- W2073683673 cites W2002294810 @default.
- W2073683673 cites W2003334958 @default.
- W2073683673 cites W2003769230 @default.
- W2073683673 cites W2004400153 @default.
- W2073683673 cites W2005857905 @default.
- W2073683673 cites W2006367248 @default.
- W2073683673 cites W2006732401 @default.
- W2073683673 cites W2007202089 @default.
- W2073683673 cites W2010113945 @default.
- W2073683673 cites W2011035069 @default.
- W2073683673 cites W2016354228 @default.
- W2073683673 cites W2017763577 @default.
- W2073683673 cites W2018478659 @default.
- W2073683673 cites W2019223944 @default.
- W2073683673 cites W2020616663 @default.
- W2073683673 cites W2022168313 @default.
- W2073683673 cites W2022429321 @default.
- W2073683673 cites W2023224640 @default.
- W2073683673 cites W2027207463 @default.
- W2073683673 cites W2027303159 @default.
- W2073683673 cites W2027919177 @default.
- W2073683673 cites W2028623046 @default.
- W2073683673 cites W2028645725 @default.
- W2073683673 cites W2029039199 @default.
- W2073683673 cites W2029389134 @default.
- W2073683673 cites W2030704166 @default.
- W2073683673 cites W2031073886 @default.
- W2073683673 cites W2031871114 @default.
- W2073683673 cites W2032054019 @default.
- W2073683673 cites W2032143580 @default.
- W2073683673 cites W2032415044 @default.
- W2073683673 cites W2034693412 @default.
- W2073683673 cites W2036165099 @default.
- W2073683673 cites W2036264239 @default.
- W2073683673 cites W2037812883 @default.
- W2073683673 cites W2038890085 @default.
- W2073683673 cites W2040102033 @default.
- W2073683673 cites W2040777839 @default.
- W2073683673 cites W2041624270 @default.
- W2073683673 cites W2042827452 @default.
- W2073683673 cites W2045890604 @default.
- W2073683673 cites W2046190361 @default.
- W2073683673 cites W2046919327 @default.
- W2073683673 cites W2047834152 @default.
- W2073683673 cites W2048035555 @default.
- W2073683673 cites W2048880297 @default.
- W2073683673 cites W2051403250 @default.
- W2073683673 cites W2052519819 @default.