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• W2073692210 endingPage "44" @default.
• W2073692210 startingPage "32" @default.
• W2073692210 abstract "Neurofilament proteins (NFs) are made by co-polymerization of three intermediate filament proteins, NF-L, NF-M and NF-H and constitute the most abundant cytoskeletal element in large myelinated axons. NFs have a well-established role as intrinsic determinants of axon caliber with all the functional implications, but the role of each individual NF subunit is much less clear. The aim of our study was to examine functional properties of large myelinated axons with altered morphology from mice bearing a targeted disruption of each NF genes (NF-L -/-, NF-M-/- and NF-H -/- mice). Membrane properties, action potentials and single axon refractory period were measured in isolated sciatic nerves in vitro, using intra-axonal microelectrode recording in conjunction with current-clamp technique. Some results were obtained from whole nerves by sucrose-gap recording. The NF-knockout mice showed several deficits in physiological properties of low-threshold fibers. In keeping with smaller axon diameter, the conduction velocity was significantly decreased in NF-L -/- and NF-M -/- transgenic animals (control, 39.9+/-1.8 m/s, NF-M -/-; 23.5+/-1. 4 m/s, and NF-L-/-; 12.0+/-0.7 m/s, mean+/-S.E.M.; intra-axonal recording; similar ratios obtained by sucrose-gap recording; 22-26 degrees C). However, in spite of their preserved caliber, large myelinated axons in NF-H -/- mice also showed a significant decrease in conduction velocity (22.8+/-1.0 m/s, mean+/-S.E.M.). Although action potential amplitudes, duration and shape did not differ between control axons and transgenic animals, the refractory period was prolonged in NF-H -/- and NF-M -/- animals. Intracellular injections of 200 ms depolarizing and hyperpolarizing currents revealed outward and inward rectification in all animal groups. In comparison to control animals, NF-H -/- mice expressed a significant decrease in outward rectification. Potassium channel blockers (4AP and TEA) and cesium ions were able to block outward and inward rectification in all myelinated axons in qualitatively the same manner. These results suggest that NF-H may have a specific role in modulating ion channel functions in large myelinated fibers." @default.
• W2073692210 created "2016-06-24" @default.
• W2073692210 creator A5020540455 @default.
• W2073692210 creator A5053072779 @default.
• W2073692210 creator A5075122820 @default.
• W2073692210 creator A5091664460 @default.
• W2073692210 date "2000-12-01" @default.
• W2073692210 modified "2023-09-27" @default.
• W2073692210 title "Electrophysiological properties of axons in mice lacking neurofilament subunit genes: disparity between conduction velocity and axon diameter in absence of NF-H" @default.
• W2073692210 cites W1748991976 @default.
• W2073692210 cites W1806399588 @default.
• W2073692210 cites W1813275637 @default.
• W2073692210 cites W1912368125 @default.
• W2073692210 cites W1954320376 @default.
• W2073692210 cites W1964014944 @default.
• W2073692210 cites W1972308707 @default.
• W2073692210 cites W1973875760 @default.
• W2073692210 cites W1979917955 @default.
• W2073692210 cites W1982647438 @default.
• W2073692210 cites W1984610550 @default.
• W2073692210 cites W1985808169 @default.
• W2073692210 cites W1986234504 @default.
• W2073692210 cites W1987277509 @default.
• W2073692210 cites W1992801408 @default.
• W2073692210 cites W1992805397 @default.
• W2073692210 cites W1992888811 @default.
• W2073692210 cites W1997757265 @default.
• W2073692210 cites W1998238515 @default.
• W2073692210 cites W2001299036 @default.
• W2073692210 cites W2003171043 @default.
• W2073692210 cites W2005941970 @default.
• W2073692210 cites W2007231028 @default.
• W2073692210 cites W2011575330 @default.
• W2073692210 cites W2013425296 @default.
• W2073692210 cites W2013473672 @default.
• W2073692210 cites W2016870828 @default.
• W2073692210 cites W2018726628 @default.
• W2073692210 cites W2021016455 @default.
• W2073692210 cites W2028531738 @default.
• W2073692210 cites W2029225256 @default.
• W2073692210 cites W2031662020 @default.
• W2073692210 cites W2038927612 @default.
• W2073692210 cites W2046637313 @default.
• W2073692210 cites W2047735926 @default.
• W2073692210 cites W2048862091 @default.
• W2073692210 cites W2050911090 @default.
• W2073692210 cites W2055753895 @default.
• W2073692210 cites W2062250460 @default.
• W2073692210 cites W2065042412 @default.
• W2073692210 cites W2071434138 @default.
• W2073692210 cites W2073059739 @default.
• W2073692210 cites W2073614451 @default.
• W2073692210 cites W2075387470 @default.
• W2073692210 cites W2077623928 @default.
• W2073692210 cites W2078546411 @default.
• W2073692210 cites W2081276194 @default.
• W2073692210 cites W2081771004 @default.
• W2073692210 cites W2082559694 @default.
• W2073692210 cites W2082889531 @default.
• W2073692210 cites W2083916407 @default.
• W2073692210 cites W2085678553 @default.
• W2073692210 cites W2086916200 @default.
• W2073692210 cites W2089094573 @default.
• W2073692210 cites W2096344366 @default.
• W2073692210 cites W2099287762 @default.
• W2073692210 cites W2106043966 @default.
• W2073692210 cites W2106218338 @default.
• W2073692210 cites W2112196515 @default.
• W2073692210 cites W2113155773 @default.
• W2073692210 cites W2113861816 @default.
• W2073692210 cites W2119297613 @default.
• W2073692210 cites W2122641411 @default.
• W2073692210 cites W2134260118 @default.
• W2073692210 cites W2158265468 @default.
• W2073692210 cites W2159163865 @default.
• W2073692210 cites W2159470622 @default.
• W2073692210 cites W2160287088 @default.
• W2073692210 cites W2163491306 @default.
• W2073692210 cites W2171602378 @default.
• W2073692210 cites W2269586762 @default.
• W2073692210 cites W2324651353 @default.
• W2073692210 cites W2470660511 @default.
• W2073692210 cites W258394342 @default.
• W2073692210 doi "https://doi.org/10.1016/s0006-8993(00)02899-7" @default.
• W2073692210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11121527" @default.
• W2073692210 hasPublicationYear "2000" @default.
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