FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073700923> ?p ?o ?g. }

• W2073700923 endingPage "82" @default.
• W2073700923 startingPage "75" @default.
• W2073700923 abstract "We have identified and characterized a set of quinoline, naphthalene and quinazoline derivatives as inhibitors of metallocarboxypeptidases, a class of metal-dependent proteolytic enzymes. The aromatic organic compounds were selected from a high-throughput screening survey and, with some exceptions, showed a good correlation between inhibitory potency and docking energy value. The in vitro inhibition tests gave K(i) values in the lower micromolar range for metallocarboxypeptidases with different specificities, and a tendency to behave as more powerful inhibitors of CPB was observed for most of the compounds tested. The kinetic results were further analyzed by structural analysis via molecular docking. The most potent aromatic organic inhibitor docks to human CPB mostly through burial of its hydrophobic moiety deep into the enzyme's active site cleft and by interacting with the catalytic zinc ion. The significance of our results in designing inhibitors against disease-related CPs from the identified ligands is examined herein." @default.
• W2073700923 created "2016-06-24" @default.
• W2073700923 creator A5040731166 @default.
• W2073700923 creator A5045647991 @default.
• W2073700923 creator A5072119318 @default.
• W2073700923 date "2008-12-18" @default.
• W2073700923 modified "2023-10-17" @default.
• W2073700923 title "Aromatic Organic Compounds as Scaffolds for Metallocarboxypeptidase Inhibitor Design" @default.
• W2073700923 cites W1903889036 @default.
• W2073700923 cites W1965567580 @default.
• W2073700923 cites W1973258316 @default.
• W2073700923 cites W1983393839 @default.
• W2073700923 cites W1986481652 @default.
• W2073700923 cites W1995828603 @default.
• W2073700923 cites W2001641653 @default.
• W2073700923 cites W2005869765 @default.
• W2073700923 cites W2009800249 @default.
• W2073700923 cites W2014123957 @default.
• W2073700923 cites W2021920356 @default.
• W2073700923 cites W2024681580 @default.
• W2073700923 cites W2028010567 @default.
• W2073700923 cites W2032154285 @default.
• W2073700923 cites W2038320709 @default.
• W2073700923 cites W2040289040 @default.
• W2073700923 cites W2045779964 @default.
• W2073700923 cites W2059833587 @default.
• W2073700923 cites W2060340923 @default.
• W2073700923 cites W2065877488 @default.
• W2073700923 cites W2073701804 @default.
• W2073700923 cites W2074631079 @default.
• W2073700923 cites W2075503331 @default.
• W2073700923 cites W2090408729 @default.
• W2073700923 cites W2103310889 @default.
• W2073700923 cites W2108156815 @default.
• W2073700923 cites W2122572489 @default.
• W2073700923 cites W2124935252 @default.
• W2073700923 cites W2142047724 @default.
• W2073700923 cites W2143690300 @default.
• W2073700923 cites W2152782018 @default.
• W2073700923 cites W2158534713 @default.
• W2073700923 cites W2165776504 @default.
• W2073700923 cites W1973181150 @default.
• W2073700923 doi "https://doi.org/10.1111/j.1747-0285.2008.00752.x" @default.
• W2073700923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19152637" @default.
• W2073700923 hasPublicationYear "2008" @default.
• W2073700923 type Work @default.
• W2073700923 sameAs 2073700923 @default.
• W2073700923 citedByCount "5" @default.
• W2073700923 countsByYear W20737009232012 @default.
• W2073700923 countsByYear W20737009232013 @default.
• W2073700923 crossrefType "journal-article" @default.
• W2073700923 hasAuthorship W2073700923A5040731166 @default.
• W2073700923 hasAuthorship W2073700923A5045647991 @default.
• W2073700923 hasAuthorship W2073700923A5072119318 @default.
• W2073700923 hasConcept C159110408 @default.
• W2073700923 hasConcept C178790620 @default.
• W2073700923 hasConcept C181199279 @default.
• W2073700923 hasConcept C185592680 @default.
• W2073700923 hasConcept C202751555 @default.
• W2073700923 hasConcept C21951064 @default.
• W2073700923 hasConcept C2776309666 @default.
• W2073700923 hasConcept C2776568683 @default.
• W2073700923 hasConcept C2777752497 @default.
• W2073700923 hasConcept C2778866207 @default.
• W2073700923 hasConcept C2779255514 @default.
• W2073700923 hasConcept C41183919 @default.
• W2073700923 hasConcept C41685203 @default.
• W2073700923 hasConcept C55493867 @default.
• W2073700923 hasConcept C71240020 @default.
• W2073700923 hasConcept C71924100 @default.
• W2073700923 hasConceptScore W2073700923C159110408 @default.
• W2073700923 hasConceptScore W2073700923C178790620 @default.
• W2073700923 hasConceptScore W2073700923C181199279 @default.
• W2073700923 hasConceptScore W2073700923C185592680 @default.
• W2073700923 hasConceptScore W2073700923C202751555 @default.
• W2073700923 hasConceptScore W2073700923C21951064 @default.
• W2073700923 hasConceptScore W2073700923C2776309666 @default.
• W2073700923 hasConceptScore W2073700923C2776568683 @default.
• W2073700923 hasConceptScore W2073700923C2777752497 @default.
• W2073700923 hasConceptScore W2073700923C2778866207 @default.
• W2073700923 hasConceptScore W2073700923C2779255514 @default.
• W2073700923 hasConceptScore W2073700923C41183919 @default.
• W2073700923 hasConceptScore W2073700923C41685203 @default.
• W2073700923 hasConceptScore W2073700923C55493867 @default.
• W2073700923 hasConceptScore W2073700923C71240020 @default.
• W2073700923 hasConceptScore W2073700923C71924100 @default.
• W2073700923 hasIssue "1" @default.
• W2073700923 hasLocation W20737009231 @default.
• W2073700923 hasLocation W20737009232 @default.
• W2073700923 hasOpenAccess W2073700923 @default.
• W2073700923 hasPrimaryLocation W20737009231 @default.
• W2073700923 hasRelatedWork W1994325596 @default.
• W2073700923 hasRelatedWork W203409259 @default.
• W2073700923 hasRelatedWork W2042185979 @default.
• W2073700923 hasRelatedWork W2188824222 @default.
• W2073700923 hasRelatedWork W2349301072 @default.
• W2073700923 hasRelatedWork W2373234669 @default.
• W2073700923 hasRelatedWork W2604155874 @default.

• next