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• W2073701099 abstract "Human cytomegalovirus (HCMV) is a frequent cause of major disease following primary infection or reactivation from latency in immunocompromised patients. Infection of non-permissive mononuclear cells is used for analyses of HCMV latency in vitro . Using this approach, it is shown here that repression of lytic gene expression following experimental infection of CD34 + cells, a site of HCMV latency in vivo , correlates with recruitment of repressive chromatin around the major immediate-early promoter (MIEP). Furthermore, long-term culture of CD34 + cells results in carriage of viral genomes in which the MIEP remains associated with transcriptionally repressive chromatin. Finally, specific differentiation of long-term cultures of infected CD34 + cells to mature dendritic cells results in acetylation of histones bound to the MIEP, concomitant loss of heterochromatin protein 1 and the reactivation of HCMV. These data are consistent with ex vivo analyses of latency and may provide a model for further analyses of the mechanisms involved during latency and reactivation." @default.
• W2073701099 created "2016-06-24" @default.
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• W2073701099 date "2005-11-01" @default.
• W2073701099 modified "2023-10-01" @default.
• W2073701099 title "An in vitro model for the regulation of human cytomegalovirus latency and reactivation in dendritic cells by chromatin remodelling" @default.
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• W2073701099 doi "https://doi.org/10.1099/vir.0.81161-0" @default.
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