FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073701518> ?p ?o ?g. }

• W2073701518 endingPage "161" @default.
• W2073701518 startingPage "151" @default.
• W2073701518 abstract "Experimental pain models inducing hyperalgesia, i.e. an increased sensitivity to noxious stimuli often present in clinical pain, are important tools for studying antinociceptive drug profiles. The correct interpretation of results obtained in these models necessitates their mechanistic understanding. This study evaluated the freeze lesion, an experimental model of hyperalgesia, in humans. Twelve healthy subjects were tested with mechanical (brush, punctuated and blunt) and electrical (5, 250, and 2000 Hz sine wave current) stimuli before and after freezing the skin, and during a computer-controlled infusion of the mu-opioid agonist remifentanil targeting five different plasma concentrations between 0 and 6 ng/ml in a two-staged, single occasion, randomized, and double blind study design. Pharmacodynamic modeling techniques were used to describe the effect of freezing and drug administration on the mechanical and electrical pain thresholds. Freezing the skin resulted in hyperalgesia to blunt and punctuated stimuli and lowered the respective pain threshold by 29 and 73%. Hyperalgesia to brushing or electrical stimuli was not detected. Remifentanil attenuated hyperalgesia to blunt stimuli about twice as potently as hyperalgesia to punctuated stimuli, as indicated by a significantly steeper linear relationship between the remifentanil plasma concentration and the increase of the pain threshold to blunt stimuli. Remifentanil attenuated electrical pain with greater potency for low frequency stimulation. The potency difference of remifentanil suggests that different neuronal mechanisms mediate hyperalgesia to blunt and punctuated stimulation. Absence of brush-evoked and electrical hyperalgesia is compatible with the view that mechanical hyperalgesia to blunt and punctuated stimulation of the freeze lesion is predominantly caused by a peripheral mechanism." @default.
• W2073701518 created "2016-06-24" @default.
• W2073701518 creator A5015880330 @default.
• W2073701518 creator A5017400006 @default.
• W2073701518 date "2003-03-01" @default.
• W2073701518 modified "2023-10-14" @default.
• W2073701518 title "The μ-opioid agonist remifentanil attenuates hyperalgesia evoked by blunt and punctuated stimuli with different potency: a pharmacological evaluation of the freeze lesion in humans" @default.
• W2073701518 cites W108060743 @default.
• W2073701518 cites W1658562319 @default.
• W2073701518 cites W1847833199 @default.
• W2073701518 cites W1869612208 @default.
• W2073701518 cites W1923569708 @default.
• W2073701518 cites W1968107265 @default.
• W2073701518 cites W1968977406 @default.
• W2073701518 cites W1971340456 @default.
• W2073701518 cites W1977885494 @default.
• W2073701518 cites W1989167075 @default.
• W2073701518 cites W1990807388 @default.
• W2073701518 cites W1994618304 @default.
• W2073701518 cites W1994705135 @default.
• W2073701518 cites W2022898812 @default.
• W2073701518 cites W2025416476 @default.
• W2073701518 cites W2028177095 @default.
• W2073701518 cites W2033980432 @default.
• W2073701518 cites W2035379177 @default.
• W2073701518 cites W2036459878 @default.
• W2073701518 cites W2041282184 @default.
• W2073701518 cites W2050294352 @default.
• W2073701518 cites W2053864414 @default.
• W2073701518 cites W2057439534 @default.
• W2073701518 cites W2058605577 @default.
• W2073701518 cites W2075103579 @default.
• W2073701518 cites W2075868413 @default.
• W2073701518 cites W2087470345 @default.
• W2073701518 cites W2090344471 @default.
• W2073701518 cites W2104519492 @default.
• W2073701518 cites W2106727887 @default.
• W2073701518 cites W2110939862 @default.
• W2073701518 cites W2125454594 @default.
• W2073701518 cites W2126309451 @default.
• W2073701518 cites W2136477585 @default.
• W2073701518 cites W2340399095 @default.
• W2073701518 cites W2440851120 @default.
• W2073701518 cites W4255594281 @default.
• W2073701518 doi "https://doi.org/10.1016/s0304-3959(02)00349-4" @default.
• W2073701518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12620606" @default.
• W2073701518 hasPublicationYear "2003" @default.
• W2073701518 type Work @default.
• W2073701518 sameAs 2073701518 @default.
• W2073701518 citedByCount "44" @default.
• W2073701518 countsByYear W20737015182012 @default.
• W2073701518 countsByYear W20737015182013 @default.
• W2073701518 countsByYear W20737015182014 @default.
• W2073701518 countsByYear W20737015182015 @default.
• W2073701518 countsByYear W20737015182017 @default.
• W2073701518 countsByYear W20737015182019 @default.
• W2073701518 countsByYear W20737015182020 @default.
• W2073701518 countsByYear W20737015182021 @default.
• W2073701518 countsByYear W20737015182023 @default.
• W2073701518 crossrefType "journal-article" @default.
• W2073701518 hasAuthorship W2073701518A5015880330 @default.
• W2073701518 hasAuthorship W2073701518A5017400006 @default.
• W2073701518 hasConcept C104211972 @default.
• W2073701518 hasConcept C126322002 @default.
• W2073701518 hasConcept C141071460 @default.
• W2073701518 hasConcept C15490471 @default.
• W2073701518 hasConcept C15744967 @default.
• W2073701518 hasConcept C169760540 @default.
• W2073701518 hasConcept C170493617 @default.
• W2073701518 hasConcept C24998067 @default.
• W2073701518 hasConcept C2776277131 @default.
• W2073701518 hasConcept C2777389121 @default.
• W2073701518 hasConcept C2778891214 @default.
• W2073701518 hasConcept C2778938600 @default.
• W2073701518 hasConcept C2779245659 @default.
• W2073701518 hasConcept C2781063702 @default.
• W2073701518 hasConcept C2781156865 @default.
• W2073701518 hasConcept C42219234 @default.
• W2073701518 hasConcept C71924100 @default.
• W2073701518 hasConcept C98274493 @default.
• W2073701518 hasConceptScore W2073701518C104211972 @default.
• W2073701518 hasConceptScore W2073701518C126322002 @default.
• W2073701518 hasConceptScore W2073701518C141071460 @default.
• W2073701518 hasConceptScore W2073701518C15490471 @default.
• W2073701518 hasConceptScore W2073701518C15744967 @default.
• W2073701518 hasConceptScore W2073701518C169760540 @default.
• W2073701518 hasConceptScore W2073701518C170493617 @default.
• W2073701518 hasConceptScore W2073701518C24998067 @default.
• W2073701518 hasConceptScore W2073701518C2776277131 @default.
• W2073701518 hasConceptScore W2073701518C2777389121 @default.
• W2073701518 hasConceptScore W2073701518C2778891214 @default.
• W2073701518 hasConceptScore W2073701518C2778938600 @default.
• W2073701518 hasConceptScore W2073701518C2779245659 @default.
• W2073701518 hasConceptScore W2073701518C2781063702 @default.
• W2073701518 hasConceptScore W2073701518C2781156865 @default.
• W2073701518 hasConceptScore W2073701518C42219234 @default.
• W2073701518 hasConceptScore W2073701518C71924100 @default.
• W2073701518 hasConceptScore W2073701518C98274493 @default.

• next