FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073708358> ?p ?o ?g. }

• W2073708358 endingPage "196" @default.
• W2073708358 startingPage "185" @default.
• W2073708358 abstract "Translation of the hepatitis C virus (HCV) genomic RNA initiates from an internal ribosome entry site (IRES) in its 5' untranslated region and requires a minimal subset of translation initiation factors to occur, namely eukaryotic initiation factor (eIF) 2 and eIF3. Low-resolution structural information has revealed how the HCV IRES RNA binds human eIF3 and the 40S ribosomal subunit and positions the start codon for initiation. However, the exact nature of the interactions between the HCV IRES RNA and the translational machinery remains unknown. Using limited proteolysis and mass spectrometry, we show that distinct regions of human eIF3 are sufficient for binding to the HCV IRES RNA and the 40S subunit. Notably, the eIF3 subunit eIF3b is protected by HCV IRES RNA binding, yet is exposed in the complex when compared to subunits eIF3e, eIF3f, eIF3h, and eIF3l. Limited proteolysis reveals that eIF3 binding to the 40S ribosomal subunit occurs through many redundant interactions that can compensate for each other. These data suggest how the HCV IRES binds to specific regions of eIF3 to target the translational machinery to the viral genomic RNA and provide a framework for modeling the architecture of intact human eIF3." @default.
• W2073708358 created "2016-06-24" @default.
• W2073708358 creator A5006606023 @default.
• W2073708358 creator A5016596564 @default.
• W2073708358 creator A5033210199 @default.
• W2073708358 creator A5041808926 @default.
• W2073708358 creator A5057207286 @default.
• W2073708358 creator A5087146972 @default.
• W2073708358 date "2010-10-01" @default.
• W2073708358 modified "2023-10-12" @default.
• W2073708358 title "Distinct Regions of Human eIF3 Are Sufficient for Binding to the HCV IRES and the 40S Ribosomal Subunit" @default.
• W2073708358 cites W101566136 @default.
• W2073708358 cites W1966279508 @default.
• W2073708358 cites W1969264016 @default.
• W2073708358 cites W1970561614 @default.
• W2073708358 cites W1975959718 @default.
• W2073708358 cites W1978446114 @default.
• W2073708358 cites W1985549728 @default.
• W2073708358 cites W1991366673 @default.
• W2073708358 cites W1993691117 @default.
• W2073708358 cites W1995383156 @default.
• W2073708358 cites W2003104968 @default.
• W2073708358 cites W2009239461 @default.
• W2073708358 cites W2010689904 @default.
• W2073708358 cites W2010874794 @default.
• W2073708358 cites W2040121752 @default.
• W2073708358 cites W2057009243 @default.
• W2073708358 cites W2066176289 @default.
• W2073708358 cites W2072933194 @default.
• W2073708358 cites W2080660790 @default.
• W2073708358 cites W2085639188 @default.
• W2073708358 cites W2088788596 @default.
• W2073708358 cites W2095582889 @default.
• W2073708358 cites W2106356459 @default.
• W2073708358 cites W2115121230 @default.
• W2073708358 cites W2137649514 @default.
• W2073708358 cites W2156628986 @default.
• W2073708358 cites W2160390885 @default.
• W2073708358 cites W2167065999 @default.
• W2073708358 doi "https://doi.org/10.1016/j.jmb.2010.07.054" @default.
• W2073708358 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2975054" @default.
• W2073708358 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20816988" @default.
• W2073708358 hasPublicationYear "2010" @default.
• W2073708358 type Work @default.
• W2073708358 sameAs 2073708358 @default.
• W2073708358 citedByCount "29" @default.
• W2073708358 countsByYear W20737083582012 @default.
• W2073708358 countsByYear W20737083582013 @default.
• W2073708358 countsByYear W20737083582014 @default.
• W2073708358 countsByYear W20737083582015 @default.
• W2073708358 countsByYear W20737083582016 @default.
• W2073708358 countsByYear W20737083582017 @default.
• W2073708358 countsByYear W20737083582018 @default.
• W2073708358 countsByYear W20737083582019 @default.
• W2073708358 countsByYear W20737083582020 @default.
• W2073708358 countsByYear W20737083582021 @default.
• W2073708358 countsByYear W20737083582022 @default.
• W2073708358 crossrefType "journal-article" @default.
• W2073708358 hasAuthorship W2073708358A5006606023 @default.
• W2073708358 hasAuthorship W2073708358A5016596564 @default.
• W2073708358 hasAuthorship W2073708358A5033210199 @default.
• W2073708358 hasAuthorship W2073708358A5041808926 @default.
• W2073708358 hasAuthorship W2073708358A5057207286 @default.
• W2073708358 hasAuthorship W2073708358A5087146972 @default.
• W2073708358 hasBestOaLocation W20737083582 @default.
• W2073708358 hasConcept C104292427 @default.
• W2073708358 hasConcept C104317684 @default.
• W2073708358 hasConcept C105580179 @default.
• W2073708358 hasConcept C112755997 @default.
• W2073708358 hasConcept C129194359 @default.
• W2073708358 hasConcept C149364088 @default.
• W2073708358 hasConcept C153911025 @default.
• W2073708358 hasConcept C301363 @default.
• W2073708358 hasConcept C4718897 @default.
• W2073708358 hasConcept C54355233 @default.
• W2073708358 hasConcept C62493599 @default.
• W2073708358 hasConcept C67705224 @default.
• W2073708358 hasConcept C67905577 @default.
• W2073708358 hasConcept C77430603 @default.
• W2073708358 hasConcept C86803240 @default.
• W2073708358 hasConcept C88478588 @default.
• W2073708358 hasConcept C95444343 @default.
• W2073708358 hasConcept C97154109 @default.
• W2073708358 hasConceptScore W2073708358C104292427 @default.
• W2073708358 hasConceptScore W2073708358C104317684 @default.
• W2073708358 hasConceptScore W2073708358C105580179 @default.
• W2073708358 hasConceptScore W2073708358C112755997 @default.
• W2073708358 hasConceptScore W2073708358C129194359 @default.
• W2073708358 hasConceptScore W2073708358C149364088 @default.
• W2073708358 hasConceptScore W2073708358C153911025 @default.
• W2073708358 hasConceptScore W2073708358C301363 @default.
• W2073708358 hasConceptScore W2073708358C4718897 @default.
• W2073708358 hasConceptScore W2073708358C54355233 @default.
• W2073708358 hasConceptScore W2073708358C62493599 @default.
• W2073708358 hasConceptScore W2073708358C67705224 @default.
• W2073708358 hasConceptScore W2073708358C67905577 @default.
• W2073708358 hasConceptScore W2073708358C77430603 @default.
• W2073708358 hasConceptScore W2073708358C86803240 @default.

• next