Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073710879> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2073710879 endingPage "27" @default.
- W2073710879 startingPage "19" @default.
- W2073710879 abstract "The xenoreactive nature of anti-Galα1–3Gal antibodies, and to a lesser extent, polyreactive antibodies, has been characterized by a number of investigators. With the advent of therapies that avoid hyperacute xenograft rejection due to anti-Galα1–3Gal antibodies coupled with the possible development of Galα1–3Gal deficient swine, the Galα1–3Gal antigen may soon cease to be a barrier to xenotransplantation. With this in mind, the potential xenoreactive nature of polyreactive antibodies was investigated using several approaches. The levels of polyreactive antibodies from the serum of newborn (n=2) and adult (n=4) baboons undergoing pulmonary xenotransplantation were evaluated. Depletion of 95% and 94% of total serum IgM, without any decrease in albumin levels, was observed in the newborn baboons. This finding indicates that the IgM present at birth and germ line polyreactive IgM was adsorbed by the xenografts. The depletion of polyreactive antibodies (43–83% reduction of anti-DNP IgM) from adult baboons was also observed following pulmonary xenotransplantation or immunoadsorption therapy plus pulmonary xenotransplantation. Additional experiments using human cord serum indicated that most human polyreactive IgM were adsorbed by pig lung homogenate and that the human polyreactive IgM bound approximately two-fold more to immobilized pig lung antigens than to immobilized human lung antigens. These findings indicate that germline polyreactive antibodies are, for the most part, xenoreactive. These data suggest that polyreactive antibodies, although autoreactive, may be more xenoreactive than autoreactive." @default.
- W2073710879 created "2016-06-24" @default.
- W2073710879 creator A5001363219 @default.
- W2073710879 creator A5011399299 @default.
- W2073710879 creator A5022126559 @default.
- W2073710879 creator A5042456708 @default.
- W2073710879 creator A5049048556 @default.
- W2073710879 creator A5078567365 @default.
- W2073710879 creator A5090323685 @default.
- W2073710879 date "2001-10-01" @default.
- W2073710879 modified "2023-10-18" @default.
- W2073710879 title "Evidence for polyreactive xenoreactive antibodies in the repertoire of human anti-swine antibodies: the ‘next’ humoral barrier to xenotransplantation?" @default.
- W2073710879 cites W138300071 @default.
- W2073710879 cites W1533481657 @default.
- W2073710879 cites W1981019503 @default.
- W2073710879 cites W1994133027 @default.
- W2073710879 cites W1997941863 @default.
- W2073710879 cites W2010524015 @default.
- W2073710879 cites W2014297236 @default.
- W2073710879 cites W2020406888 @default.
- W2073710879 cites W2032121728 @default.
- W2073710879 cites W203320501 @default.
- W2073710879 cites W2036168530 @default.
- W2073710879 cites W2052556732 @default.
- W2073710879 cites W2052847242 @default.
- W2073710879 cites W2055202919 @default.
- W2073710879 cites W2066023848 @default.
- W2073710879 cites W2071094280 @default.
- W2073710879 cites W2080249692 @default.
- W2073710879 cites W2086866412 @default.
- W2073710879 cites W2088468634 @default.
- W2073710879 cites W2091820223 @default.
- W2073710879 cites W2142780368 @default.
- W2073710879 cites W2272276626 @default.
- W2073710879 cites W289878760 @default.
- W2073710879 cites W50804317 @default.
- W2073710879 doi "https://doi.org/10.1016/s0966-3274(01)00047-8" @default.
- W2073710879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11680568" @default.
- W2073710879 hasPublicationYear "2001" @default.
- W2073710879 type Work @default.
- W2073710879 sameAs 2073710879 @default.
- W2073710879 citedByCount "11" @default.
- W2073710879 countsByYear W20737108792012 @default.
- W2073710879 countsByYear W20737108792017 @default.
- W2073710879 countsByYear W20737108792019 @default.
- W2073710879 crossrefType "journal-article" @default.
- W2073710879 hasAuthorship W2073710879A5001363219 @default.
- W2073710879 hasAuthorship W2073710879A5011399299 @default.
- W2073710879 hasAuthorship W2073710879A5022126559 @default.
- W2073710879 hasAuthorship W2073710879A5042456708 @default.
- W2073710879 hasAuthorship W2073710879A5049048556 @default.
- W2073710879 hasAuthorship W2073710879A5078567365 @default.
- W2073710879 hasAuthorship W2073710879A5090323685 @default.
- W2073710879 hasConcept C126322002 @default.
- W2073710879 hasConcept C147483822 @default.
- W2073710879 hasConcept C159654299 @default.
- W2073710879 hasConcept C203014093 @default.
- W2073710879 hasConcept C2776553844 @default.
- W2073710879 hasConcept C2778442404 @default.
- W2073710879 hasConcept C2780898057 @default.
- W2073710879 hasConcept C2911091166 @default.
- W2073710879 hasConcept C71924100 @default.
- W2073710879 hasConcept C86803240 @default.
- W2073710879 hasConceptScore W2073710879C126322002 @default.
- W2073710879 hasConceptScore W2073710879C147483822 @default.
- W2073710879 hasConceptScore W2073710879C159654299 @default.
- W2073710879 hasConceptScore W2073710879C203014093 @default.
- W2073710879 hasConceptScore W2073710879C2776553844 @default.
- W2073710879 hasConceptScore W2073710879C2778442404 @default.
- W2073710879 hasConceptScore W2073710879C2780898057 @default.
- W2073710879 hasConceptScore W2073710879C2911091166 @default.
- W2073710879 hasConceptScore W2073710879C71924100 @default.
- W2073710879 hasConceptScore W2073710879C86803240 @default.
- W2073710879 hasIssue "1" @default.
- W2073710879 hasLocation W20737108791 @default.
- W2073710879 hasLocation W20737108792 @default.
- W2073710879 hasOpenAccess W2073710879 @default.
- W2073710879 hasPrimaryLocation W20737108791 @default.
- W2073710879 hasRelatedWork W1564296543 @default.
- W2073710879 hasRelatedWork W1741762729 @default.
- W2073710879 hasRelatedWork W1870505889 @default.
- W2073710879 hasRelatedWork W1908561193 @default.
- W2073710879 hasRelatedWork W1931067834 @default.
- W2073710879 hasRelatedWork W1977905136 @default.
- W2073710879 hasRelatedWork W2040191638 @default.
- W2073710879 hasRelatedWork W2099244599 @default.
- W2073710879 hasRelatedWork W2295035390 @default.
- W2073710879 hasRelatedWork W3181630718 @default.
- W2073710879 hasVolume "9" @default.
- W2073710879 isParatext "false" @default.
- W2073710879 isRetracted "false" @default.
- W2073710879 magId "2073710879" @default.
- W2073710879 workType "article" @default.