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- W2073720976 abstract "Anoxic-ischaemic neuronal damage has been defined by a combined light and electron microscope study of the neocortex and hippocampus of rats exposed to nitrogen intermittently during a period of 40 min with (“Levine preparation”) and without (“nitrogen only” animals) interruption of blood flow in the right common carotid artery. The animals were killed by perfusion-fixation with glutaraldehyde after survivals (measured from the end of exposure to nitrogen) of 45 min to 2 hr. Microvacuolation, the earliest stage of anoxic-ischaemic neuronal damage, and ischaemic cell change were observed in the neocortex and hippocampus of both groups of animals while ischaemic cell change with incrustations was confined to the neocortex. Ultrastructural examination showed that the majority of microvacuoles in the neuronal cytoplasm correspond to swollen mitochondria. Dilatations of both smooth and granular endoplasmic reticulum accompanied the mitochondrial swelling. There was an associated apparent increase in ribosomes and in cytoplasmic matrix density. The evolution of ischaemic cell change with an without incrustations appeared to occur by a progressive condensation of the cytoplasm between all intraneuronal dilated spaces, sometimes accompanied by shrinkage of the swollen mitochondria. Surface irregularities and the apparent isolation of dense areas of the neuronal soma by areas of lesser electron density appeared to represent the incrustations of light microscopy. Swollen astrocytic processes surrounded the damaged neurones at all stages of the cell change. Ultrastructural changes occurring in axon terminals and dendrites are described." @default.
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- W2073720976 date "1972-05-01" @default.
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- W2073720976 title "Anoxic-ischaemic cell change in rat brain light microscopic and fine-structural observations" @default.
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- W2073720976 doi "https://doi.org/10.1016/0022-510x(72)90102-5" @default.
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