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- W2073722122 abstract "Abstract: We investigated the clinical response of chronic heart failure patients with β 2 ‐adrenergic receptor Gln 27 →Glu polymorphism treated for 6 months with carvedilol, a α/β‐antagonist with antioxidant properties. The 6‐min. walk test, the left ventricular ejection fraction, heart rate, plasma norepinephrine and malondialdehyde, a stress oxidative marker, concentrations were evaluated at baseline and after treatment for 6 months with carvedilol in 33 stable chronic heart failure patients with the Gln 27 →Gluβ 2 ‐adrenergic receptor polymorphism. Carvedilol significantly increased the left ventricular ejection fraction, while decreasing the heart rate and malondialdehyde plasma concentrations in chronic heart failure patients with the Glu 27 β 2 ‐adrenergic receptor allele. There were however, no significant changes in patients with the Gln 27 β 2 ‐adrenergic receptor variant." @default.
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- W2073722122 date "2009-04-08" @default.
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- W2073722122 title "Gln<sup>27</sup>→Gluβ<sub>2</sub>-Adrenergic Receptor Polymorphism in Heart Failure Patients: Differential Clinical and Oxidative Response to Carvedilol" @default.
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- W2073722122 doi "https://doi.org/10.1111/j.1742-7843.2008.00370.x" @default.
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