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- W2073722729 abstract "A notable feature of poxviruses is their ability to inhibit the antiviral response, including the nuclear factor kappa B (NFκB) pathway. NFκB is a transcription factor that is sequestered in the cytoplasm until cell stimulation, and relies on the SCF (Skp1, culllin-1, F-box) ubiquitin ligase to target its inhibitor, IκBα, for degradation. IκBα is recruited to the SCF by the F-box domain-containing protein βTrCP. Here, we show that ectromelia virus, the causative agent of mousepox, encodes four F-box-containing proteins, EVM002, EVM005, EVM154, and EVM165, all of which contain Ankyrin (Ank) domains. The Ank/F-box proteins inhibit NFκB nuclear translocation, and this inhibition is dependent on the F-box domain. We also demonstrate that EVM002, EVM005, EVM154, and EVM165 prevent IκBα degradation, suggesting that they target the SCF. This study identifies a new mechanism by which ectromelia virus inhibits NFκB." @default.
- W2073722729 created "2016-06-24" @default.
- W2073722729 creator A5012690304 @default.
- W2073722729 creator A5023544493 @default.
- W2073722729 creator A5068172568 @default.
- W2073722729 date "2014-11-01" @default.
- W2073722729 modified "2023-09-29" @default.
- W2073722729 title "Ectromelia virus encodes a family of Ankyrin/F-box proteins that regulate NFκB" @default.
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- W2073722729 doi "https://doi.org/10.1016/j.virol.2014.08.030" @default.
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- W2073722729 hasPublicationYear "2014" @default.
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