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• W2073734090 abstract "In the pig-to-nonimmunosuppressed baboon artery patch model, a graft from an α1,3-galactosyltransferase gene-knockout pig transgenic for human CD46 (GTKO/CD46) induces a significant adaptive immune response (elicited anti-pig antibody response, increase in T cell proliferation on MLR, cellular infiltration of the graft), which is effectively prevented by anti-CD154mAb-based therapy.As anti-CD154mAb is currently not clinically applicable, we evaluated whether it could be replaced by CD28/B7 pathway blockade or by blockade of both pathways (using belatacept + anti-CD40mAb [2C10R4]). We further investigated whether a patch from a GTKO/CD46 pig with a mutant human MHC class II transactivator (CIITA-DN) gene would allow reduction in the immunosuppressive therapy administered.When grafts from GTKO/CD46 pigs were transplanted with blockade of both pathways, a minimal or insignificant adaptive response was documented. When a GTKO/CD46/CIITA-DN graft was transplanted, but no immunosuppressive therapy was administered, a marked adaptive response was documented. In the presence of CD28/B7 pathway blockade (abatacept or belatacept), there was a weak adaptive response that was diminished when compared with that to a GTKO/CD46 graft. Blockade of both pathways prevented an adaptive response.Although expression of the mutant MHC CIITA-DN gene was associated with a reduced adaptive immune response when immunosuppressive therapy was inadequate, when blockade of both the CD40/CD154 and CD28/B7 pathways was present, the response even to a GTKO/CD46 graft was suppressed. This was confirmed after GTKO/CD46 heart transplantation in baboons." @default.
• W2073734090 created "2016-06-24" @default.
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• W2073734090 date "2015-03-01" @default.
• W2073734090 modified "2023-10-15" @default.
• W2073734090 title "Initial in vivo experience of pig artery patch transplantation in baboons using mutant MHC (CIITA-DN) pigs" @default.
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• W2073734090 doi "https://doi.org/10.1016/j.trim.2015.02.003" @default.
• W2073734090 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4368496" @default.
• W2073734090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25687023" @default.
• W2073734090 hasPublicationYear "2015" @default.
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