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• W2073734975 abstract "In the present study, we evaluated the potential neuroprotective effect of granulocyte colony-stimulating factor (G-CSF), a hematopoietic growth factor in two different culture models in which dopaminergic (DA) neurons die selectively: first, in a culture model in which death of DA neurons occurs spontaneously and second, in a toxin-based paradigm, the in vitro 1-methyl-4-phenylpyridinium model of PD. In neither of the two models, a treatment with G-CSF, could prevent or halt the progressive neurodegeneration. However, we cannot rule out that G-CSF might exert neuroprotective or even deleterious effects in in vivo models of PD, based on the significant increase in the number of microglial cells observed after G-CSF treatment." @default.
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• W2073734975 date "2005-07-01" @default.
• W2073734975 modified "2023-10-18" @default.
• W2073734975 title "Granulocyte colony-stimulating factor is not protective against selective dopaminergic cell death in vitro" @default.
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• W2073734975 doi "https://doi.org/10.1016/j.neulet.2005.03.041" @default.
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