Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073742453> ?p ?o ?g. }
- W2073742453 endingPage "765" @default.
- W2073742453 startingPage "758" @default.
- W2073742453 abstract "Background and purpose: The objective of this study was to investigate the possible interactions between the cannabinoid and cholinergic systems in memory and learning processes by using genetic and pharmacological approaches in two different behavioural models, the active avoidance and the object recognition test. Experimental approach: The effects induced by nicotine, physostigmine and scopolamine were studied in CB 1 receptor knockout and wild‐type mice in the active avoidance paradigm. In addition, the effects of pretreatment with the CB 1 receptor antagonist rimonabant were evaluated on the responses induced by nicotine in the active avoidance and the object recognition tasks in wild‐type mice. Key results: Nicotine (0.5 mgkg –1 s.c.) did not modify the performance of CB 1 knockout and wild‐type mice in this model, whereas scopolamine (0.5 mgkg –1 i.p.) impaired the performance in both genotypes. Physostigmine (0.1 mgkg –1 i.p.) increased the active avoidance performance in wild‐type but not in CB 1 knockout mice. Rimonabant (0.3, 1, 3, and 10 mgkg –1 ) did not modify the performance in the active avoidance test, given alone or co‐administered with nicotine. In contrast, nicotine enhanced the performance in the object recognition task but this response was attenuated by rimonabant co‐administration. Conclusions and implications: The present findings revealed that the cognitive effects of nicotine and physostigmine were attenuated in the absence of CB 1 receptor activity. Scopolamine effects were independent from CB 1 receptors. British Journal of Pharmacology (2007) 150 , 758–765. doi: 10.1038/sj.bjp.0707152" @default.
- W2073742453 created "2016-06-24" @default.
- W2073742453 creator A5022431389 @default.
- W2073742453 creator A5023104507 @default.
- W2073742453 creator A5029010793 @default.
- W2073742453 creator A5037897982 @default.
- W2073742453 creator A5059179300 @default.
- W2073742453 date "2007-03-01" @default.
- W2073742453 modified "2023-10-18" @default.
- W2073742453 title "Genetic and pharmacological approaches to evaluate the interaction between the cannabinoid and cholinergic systems in cognitive processes" @default.
- W2073742453 cites W155772752 @default.
- W2073742453 cites W1602389925 @default.
- W2073742453 cites W1654380405 @default.
- W2073742453 cites W1667014641 @default.
- W2073742453 cites W1971277989 @default.
- W2073742453 cites W1972995286 @default.
- W2073742453 cites W1974225403 @default.
- W2073742453 cites W1977758399 @default.
- W2073742453 cites W1979347858 @default.
- W2073742453 cites W1982291289 @default.
- W2073742453 cites W1983885464 @default.
- W2073742453 cites W1985637593 @default.
- W2073742453 cites W1986199494 @default.
- W2073742453 cites W1989008646 @default.
- W2073742453 cites W1993681287 @default.
- W2073742453 cites W2006489620 @default.
- W2073742453 cites W2020862885 @default.
- W2073742453 cites W2027180925 @default.
- W2073742453 cites W2029181309 @default.
- W2073742453 cites W2039398668 @default.
- W2073742453 cites W2041601285 @default.
- W2073742453 cites W2045122897 @default.
- W2073742453 cites W2047189940 @default.
- W2073742453 cites W2049670675 @default.
- W2073742453 cites W2056188558 @default.
- W2073742453 cites W2064039790 @default.
- W2073742453 cites W2064128689 @default.
- W2073742453 cites W2070992907 @default.
- W2073742453 cites W2071122099 @default.
- W2073742453 cites W2072441360 @default.
- W2073742453 cites W2073399948 @default.
- W2073742453 cites W2074311381 @default.
- W2073742453 cites W2078858579 @default.
- W2073742453 cites W2086721550 @default.
- W2073742453 cites W2087587748 @default.
- W2073742453 cites W2089711120 @default.
- W2073742453 cites W2090737341 @default.
- W2073742453 cites W2091673195 @default.
- W2073742453 cites W2097532003 @default.
- W2073742453 cites W2099638088 @default.
- W2073742453 cites W2100598248 @default.
- W2073742453 cites W2107278694 @default.
- W2073742453 cites W2118091961 @default.
- W2073742453 cites W2124894648 @default.
- W2073742453 cites W2127372827 @default.
- W2073742453 cites W2131354127 @default.
- W2073742453 cites W2151772235 @default.
- W2073742453 cites W2158553737 @default.
- W2073742453 cites W2160485854 @default.
- W2073742453 cites W2162653297 @default.
- W2073742453 cites W2171584675 @default.
- W2073742453 doi "https://doi.org/10.1038/sj.bjp.0707152" @default.
- W2073742453 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2013866" @default.
- W2073742453 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17279087" @default.
- W2073742453 hasPublicationYear "2007" @default.
- W2073742453 type Work @default.
- W2073742453 sameAs 2073742453 @default.
- W2073742453 citedByCount "19" @default.
- W2073742453 countsByYear W20737424532012 @default.
- W2073742453 countsByYear W20737424532014 @default.
- W2073742453 countsByYear W20737424532015 @default.
- W2073742453 countsByYear W20737424532017 @default.
- W2073742453 countsByYear W20737424532018 @default.
- W2073742453 countsByYear W20737424532021 @default.
- W2073742453 crossrefType "journal-article" @default.
- W2073742453 hasAuthorship W2073742453A5022431389 @default.
- W2073742453 hasAuthorship W2073742453A5023104507 @default.
- W2073742453 hasAuthorship W2073742453A5029010793 @default.
- W2073742453 hasAuthorship W2073742453A5037897982 @default.
- W2073742453 hasAuthorship W2073742453A5059179300 @default.
- W2073742453 hasBestOaLocation W20737424531 @default.
- W2073742453 hasConcept C126322002 @default.
- W2073742453 hasConcept C148001335 @default.
- W2073742453 hasConcept C15744967 @default.
- W2073742453 hasConcept C169760540 @default.
- W2073742453 hasConcept C170493617 @default.
- W2073742453 hasConcept C22885893 @default.
- W2073742453 hasConcept C2776433454 @default.
- W2073742453 hasConcept C2776663719 @default.
- W2073742453 hasConcept C2776880047 @default.
- W2073742453 hasConcept C2776885963 @default.
- W2073742453 hasConcept C2779547902 @default.
- W2073742453 hasConcept C2780871563 @default.
- W2073742453 hasConcept C71924100 @default.
- W2073742453 hasConcept C98274493 @default.
- W2073742453 hasConceptScore W2073742453C126322002 @default.
- W2073742453 hasConceptScore W2073742453C148001335 @default.
- W2073742453 hasConceptScore W2073742453C15744967 @default.