Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073747872> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2073747872 endingPage "96" @default.
- W2073747872 startingPage "88" @default.
- W2073747872 abstract "Randomized trials have shown an improvement in progression-free survival rates with adjuvant radiation therapy (ART) after radical prostatectomy for patients with a high risk of cancer recurrence. Less is known about the relative advantages and disadvantages of initial observation with delayed salvage radiation therapy (SRT).To examine the results of SRT in a large single-surgeon radical prostatectomy series.From a radical prostatectomy database, we identified 859 men with positive surgical margins (SM+), extracapsular tumor extension (ECE), or seminal vesicle invasion (SVI) who chose to defer ART. Following a period of initial observation, 192 ultimately received SRT for prostate-specific antigen (PSA) progression.Survival analysis was performed to examine the outcomes of initial observation followed by SRT.In patients with SM+/ECE and SVI, the 7-yr PSA progression-free survival rates with observation were 62% and 32%, respectively. Among those who had PSA progression, 56% and 26%, respectively, maintained an undetectable PSA for 5 yr after SRT. The long-term rates of undetectable PSA associated with an SRT strategy were 83% and 50% for men with SM+/ECE and SVI, respectively. In the subset of 716 men who did not receive any hormonal therapy, the corresponding long-term rates of undetectable PSA were 91% and 75%, respectively.Following radical prostatectomy, initial observation followed by delayed SRT at the time of PSA recurrence is an effective strategy for selected patients with SM+/ECE. Some patients with SVI may also benefit from this strategy. However, additional prospective studies are necessary to further examine the survival outcomes following SRT." @default.
- W2073747872 created "2016-06-24" @default.
- W2073747872 creator A5021674174 @default.
- W2073747872 creator A5031483568 @default.
- W2073747872 creator A5065869555 @default.
- W2073747872 creator A5085409087 @default.
- W2073747872 date "2008-07-01" @default.
- W2073747872 modified "2023-10-16" @default.
- W2073747872 title "Long-Term Rates of Undetectable PSA with Initial Observation and Delayed Salvage Radiotherapy after Radical Prostatectomy" @default.
- W2073747872 cites W1975323370 @default.
- W2073747872 cites W2012696600 @default.
- W2073747872 cites W2024516085 @default.
- W2073747872 cites W2040659915 @default.
- W2073747872 cites W2048012145 @default.
- W2073747872 cites W2101889062 @default.
- W2073747872 cites W2104870101 @default.
- W2073747872 cites W2105684279 @default.
- W2073747872 cites W2131034864 @default.
- W2073747872 cites W2137491531 @default.
- W2073747872 cites W2157132624 @default.
- W2073747872 cites W2157694610 @default.
- W2073747872 cites W2159790321 @default.
- W2073747872 cites W4246886052 @default.
- W2073747872 doi "https://doi.org/10.1016/j.eururo.2008.03.066" @default.
- W2073747872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18400368" @default.
- W2073747872 hasPublicationYear "2008" @default.
- W2073747872 type Work @default.
- W2073747872 sameAs 2073747872 @default.
- W2073747872 citedByCount "27" @default.
- W2073747872 countsByYear W20737478722012 @default.
- W2073747872 countsByYear W20737478722013 @default.
- W2073747872 countsByYear W20737478722014 @default.
- W2073747872 countsByYear W20737478722017 @default.
- W2073747872 crossrefType "journal-article" @default.
- W2073747872 hasAuthorship W2073747872A5021674174 @default.
- W2073747872 hasAuthorship W2073747872A5031483568 @default.
- W2073747872 hasAuthorship W2073747872A5065869555 @default.
- W2073747872 hasAuthorship W2073747872A5085409087 @default.
- W2073747872 hasConcept C121608353 @default.
- W2073747872 hasConcept C126322002 @default.
- W2073747872 hasConcept C126894567 @default.
- W2073747872 hasConcept C141071460 @default.
- W2073747872 hasConcept C2776694085 @default.
- W2073747872 hasConcept C2779466945 @default.
- W2073747872 hasConcept C2780192828 @default.
- W2073747872 hasConcept C2780775027 @default.
- W2073747872 hasConcept C2781406297 @default.
- W2073747872 hasConcept C509974204 @default.
- W2073747872 hasConcept C71924100 @default.
- W2073747872 hasConceptScore W2073747872C121608353 @default.
- W2073747872 hasConceptScore W2073747872C126322002 @default.
- W2073747872 hasConceptScore W2073747872C126894567 @default.
- W2073747872 hasConceptScore W2073747872C141071460 @default.
- W2073747872 hasConceptScore W2073747872C2776694085 @default.
- W2073747872 hasConceptScore W2073747872C2779466945 @default.
- W2073747872 hasConceptScore W2073747872C2780192828 @default.
- W2073747872 hasConceptScore W2073747872C2780775027 @default.
- W2073747872 hasConceptScore W2073747872C2781406297 @default.
- W2073747872 hasConceptScore W2073747872C509974204 @default.
- W2073747872 hasConceptScore W2073747872C71924100 @default.
- W2073747872 hasIssue "1" @default.
- W2073747872 hasLocation W20737478721 @default.
- W2073747872 hasLocation W20737478722 @default.
- W2073747872 hasOpenAccess W2073747872 @default.
- W2073747872 hasPrimaryLocation W20737478721 @default.
- W2073747872 hasRelatedWork W1967410728 @default.
- W2073747872 hasRelatedWork W2026113581 @default.
- W2073747872 hasRelatedWork W2093197441 @default.
- W2073747872 hasRelatedWork W2329894078 @default.
- W2073747872 hasRelatedWork W2402249956 @default.
- W2073747872 hasRelatedWork W2475373842 @default.
- W2073747872 hasRelatedWork W2517713070 @default.
- W2073747872 hasRelatedWork W2974470461 @default.
- W2073747872 hasRelatedWork W3150909901 @default.
- W2073747872 hasRelatedWork W4239741083 @default.
- W2073747872 hasVolume "54" @default.
- W2073747872 isParatext "false" @default.
- W2073747872 isRetracted "false" @default.
- W2073747872 magId "2073747872" @default.
- W2073747872 workType "article" @default.