Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073751586> ?p ?o ?g. }
- W2073751586 abstract "The Na+/K+-ATPase generates ion gradients across the plasma membrane, essential for multiple cellular functions. In mammals, four different Na+/K+-ATPase α-subunit isoforms are associated with characteristic cell-type expression profiles and kinetics. We found the zebrafish α2Na+/K+-ATPase associated with striated muscles and that α2Na+/K+-ATPase knockdown causes a significant depolarization of the resting membrane potential in slow-twitch fibers of skeletal muscles. Abrupt mechanosensory responses were observed in α2Na+/K+-ATPase deficient embryos, possibly linked to a postsynaptic defect. The α2Na+/K+-ATPase deficiency reduced the heart rate and caused a loss of left-right asymmetry in the heart tube. Similar phenotypes observed by knockdown of the Na+/Ca2+ exchanger indicated a role for the interplay between these two proteins on the observed phenotypes. Furthermore, proteomics identified up- and down-regulation of specific phenotype-related proteins, such as parvalbumin, CaM, GFAP and multiple kinases, thus highlighting a potential proteome change associated with the dynamics of α2Na+/K+-ATPase. Taken together, our findings display that zebrafish α2Na+/K+-ATPase is important for skeletal and heart muscle functions." @default.
- W2073751586 created "2016-06-24" @default.
- W2073751586 creator A5007975554 @default.
- W2073751586 creator A5012891601 @default.
- W2073751586 creator A5014270850 @default.
- W2073751586 creator A5028082284 @default.
- W2073751586 creator A5031299935 @default.
- W2073751586 creator A5033337407 @default.
- W2073751586 creator A5036245919 @default.
- W2073751586 creator A5041160849 @default.
- W2073751586 creator A5079818685 @default.
- W2073751586 creator A5080541529 @default.
- W2073751586 date "2012-01-01" @default.
- W2073751586 modified "2023-10-16" @default.
- W2073751586 title "The α2Na+/K+-ATPase is critical for skeletal and heart muscle function in zebrafish" @default.
- W2073751586 cites W1485996519 @default.
- W2073751586 cites W1947859348 @default.
- W2073751586 cites W1963957628 @default.
- W2073751586 cites W1969547023 @default.
- W2073751586 cites W1971262350 @default.
- W2073751586 cites W1976684150 @default.
- W2073751586 cites W1977128775 @default.
- W2073751586 cites W1981762712 @default.
- W2073751586 cites W1986026709 @default.
- W2073751586 cites W1994279301 @default.
- W2073751586 cites W1994695193 @default.
- W2073751586 cites W1995839968 @default.
- W2073751586 cites W1995953935 @default.
- W2073751586 cites W1996054526 @default.
- W2073751586 cites W1997754115 @default.
- W2073751586 cites W2001930317 @default.
- W2073751586 cites W2004254765 @default.
- W2073751586 cites W2009396796 @default.
- W2073751586 cites W2010307662 @default.
- W2073751586 cites W2014779461 @default.
- W2073751586 cites W2018241116 @default.
- W2073751586 cites W2021264472 @default.
- W2073751586 cites W2024728309 @default.
- W2073751586 cites W2037290404 @default.
- W2073751586 cites W2043687273 @default.
- W2073751586 cites W2048925802 @default.
- W2073751586 cites W2053188090 @default.
- W2073751586 cites W2054224074 @default.
- W2073751586 cites W2054527457 @default.
- W2073751586 cites W2055448024 @default.
- W2073751586 cites W2063502873 @default.
- W2073751586 cites W2072856314 @default.
- W2073751586 cites W2079362172 @default.
- W2073751586 cites W2081607263 @default.
- W2073751586 cites W2089897656 @default.
- W2073751586 cites W2094442354 @default.
- W2073751586 cites W2095190998 @default.
- W2073751586 cites W2096251733 @default.
- W2073751586 cites W2101967150 @default.
- W2073751586 cites W2104166001 @default.
- W2073751586 cites W2110998515 @default.
- W2073751586 cites W2111479560 @default.
- W2073751586 cites W2116672207 @default.
- W2073751586 cites W2117346388 @default.
- W2073751586 cites W2119660325 @default.
- W2073751586 cites W2122717958 @default.
- W2073751586 cites W2123608584 @default.
- W2073751586 cites W2123702622 @default.
- W2073751586 cites W2124352183 @default.
- W2073751586 cites W2125295969 @default.
- W2073751586 cites W2125349610 @default.
- W2073751586 cites W2126657731 @default.
- W2073751586 cites W2128852959 @default.
- W2073751586 cites W2128862717 @default.
- W2073751586 cites W2132595000 @default.
- W2073751586 cites W2142048790 @default.
- W2073751586 cites W2148624302 @default.
- W2073751586 cites W2157438829 @default.
- W2073751586 cites W2158343977 @default.
- W2073751586 cites W2160268500 @default.
- W2073751586 cites W2161283017 @default.
- W2073751586 cites W2162040432 @default.
- W2073751586 cites W2169934703 @default.
- W2073751586 cites W2187015159 @default.
- W2073751586 cites W2312098387 @default.
- W2073751586 cites W4233895158 @default.
- W2073751586 doi "https://doi.org/10.1242/jcs.115808" @default.
- W2073751586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23097043" @default.
- W2073751586 hasPublicationYear "2012" @default.
- W2073751586 type Work @default.
- W2073751586 sameAs 2073751586 @default.
- W2073751586 citedByCount "17" @default.
- W2073751586 countsByYear W20737515862013 @default.
- W2073751586 countsByYear W20737515862014 @default.
- W2073751586 countsByYear W20737515862015 @default.
- W2073751586 countsByYear W20737515862016 @default.
- W2073751586 countsByYear W20737515862017 @default.
- W2073751586 countsByYear W20737515862018 @default.
- W2073751586 countsByYear W20737515862021 @default.
- W2073751586 countsByYear W20737515862022 @default.
- W2073751586 crossrefType "journal-article" @default.
- W2073751586 hasAuthorship W2073751586A5007975554 @default.
- W2073751586 hasAuthorship W2073751586A5012891601 @default.
- W2073751586 hasAuthorship W2073751586A5014270850 @default.
- W2073751586 hasAuthorship W2073751586A5028082284 @default.