FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073753432> ?p ?o ?g. }

• W2073753432 abstract "There is a limited understanding of the cellular regulation of HBV gene expression in differentiated hepatocytes. We previously demonstrated that HBV replication inversely correlates with cell proliferation and DNA synthesis. In this report, temperature-induced modulation of cell growth was used as a novel approach to study HBV gene expression in the absence of indirect effects from drugs or serum deprivation. We observed markedly elevated levels of hepatic HBV mRNA expression from integrated and episomal HBV DNA at 32 degrees C. Additionally, hepatoblastoma cells cultured at 32 degrees C expressed increased levels of albumin mRNA and decreased levels of c-myc mRNA, which demonstrates that liver-derived cells cultured at low temperature exhibit characteristics of functional and differentiated hepatocytes. In transiently transfected HepG2 cells cultured at 32 degrees C, the HBV enhancer 1 activated the X promoter and core/pregenomic promoter by 7.3- and 28-fold, respectively. In the absence of enhancer 1, core/pregenomic promoter activity was 2.4-fold higher than the X promoter in HepG2 cells at 32 degrees C. In contrast, enhancer 1 exclusively activated the X promoter in transfected non-liver cells at 32 degrees C. Therefore, the core/pregenomic promoter exhibits strict liver-specificity at low temperature. This work supports the hypothesis that HBV replication and gene expression are optimal in non-activated hepatocytes, and provides a novel system for delineating molecular aspects of the HBV replication process." @default.
• W2073753432 created "2016-06-24" @default.
• W2073753432 creator A5000925693 @default.
• W2073753432 creator A5026373551 @default.
• W2073753432 creator A5075593120 @default.
• W2073753432 creator A5088195327 @default.
• W2073753432 date "2000-01-01" @default.
• W2073753432 modified "2023-09-27" @default.
• W2073753432 title "Induction of hepatitis B virus gene expression at low temperature" @default.
• W2073753432 cites W1480719064 @default.
• W2073753432 cites W1480852720 @default.
• W2073753432 cites W1523170992 @default.
• W2073753432 cites W1559998622 @default.
• W2073753432 cites W1583015460 @default.
• W2073753432 cites W1588851944 @default.
• W2073753432 cites W1611884612 @default.
• W2073753432 cites W1690683413 @default.
• W2073753432 cites W1749788643 @default.
• W2073753432 cites W1795594615 @default.
• W2073753432 cites W1837123680 @default.
• W2073753432 cites W1883539422 @default.
• W2073753432 cites W1906577897 @default.
• W2073753432 cites W1962682498 @default.
• W2073753432 cites W1969870579 @default.
• W2073753432 cites W1970505893 @default.
• W2073753432 cites W1976179286 @default.
• W2073753432 cites W1979520405 @default.
• W2073753432 cites W1983130061 @default.
• W2073753432 cites W1997582694 @default.
• W2073753432 cites W2009227323 @default.
• W2073753432 cites W2010338556 @default.
• W2073753432 cites W2012388553 @default.
• W2073753432 cites W2013054809 @default.
• W2073753432 cites W2018048942 @default.
• W2073753432 cites W2021253208 @default.
• W2073753432 cites W2032781689 @default.
• W2073753432 cites W2033522034 @default.
• W2073753432 cites W2034296773 @default.
• W2073753432 cites W2035667825 @default.
• W2073753432 cites W2038693683 @default.
• W2073753432 cites W2042403784 @default.
• W2073753432 cites W2043550216 @default.
• W2073753432 cites W2050274505 @default.
• W2073753432 cites W2050343136 @default.
• W2073753432 cites W2054464808 @default.
• W2073753432 cites W2058349670 @default.
• W2073753432 cites W2059612591 @default.
• W2073753432 cites W2062810379 @default.
• W2073753432 cites W2068670805 @default.
• W2073753432 cites W2080054391 @default.
• W2073753432 cites W2083703476 @default.
• W2073753432 cites W2088249412 @default.
• W2073753432 cites W2090344376 @default.
• W2073753432 cites W2091995339 @default.
• W2073753432 cites W2092675732 @default.
• W2073753432 cites W2095620987 @default.
• W2073753432 cites W2096808350 @default.
• W2073753432 cites W2109970232 @default.
• W2073753432 cites W2114769263 @default.
• W2073753432 cites W2137153880 @default.
• W2073753432 cites W2153765963 @default.
• W2073753432 cites W2159146123 @default.
• W2073753432 cites W2166993990 @default.
• W2073753432 cites W2494298625 @default.
• W2073753432 doi "https://doi.org/10.1016/s0167-4781(99)00231-6" @default.
• W2073753432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10786618" @default.
• W2073753432 hasPublicationYear "2000" @default.
• W2073753432 type Work @default.
• W2073753432 sameAs 2073753432 @default.
• W2073753432 citedByCount "3" @default.
• W2073753432 countsByYear W20737534322014 @default.
• W2073753432 crossrefType "journal-article" @default.
• W2073753432 hasAuthorship W2073753432A5000925693 @default.
• W2073753432 hasAuthorship W2073753432A5026373551 @default.
• W2073753432 hasAuthorship W2073753432A5075593120 @default.
• W2073753432 hasAuthorship W2073753432A5088195327 @default.
• W2073753432 hasConcept C101762097 @default.
• W2073753432 hasConcept C104317684 @default.
• W2073753432 hasConcept C105580179 @default.
• W2073753432 hasConcept C111936080 @default.
• W2073753432 hasConcept C126322002 @default.
• W2073753432 hasConcept C150194340 @default.
• W2073753432 hasConcept C153911025 @default.
• W2073753432 hasConcept C159047783 @default.
• W2073753432 hasConcept C181674461 @default.
• W2073753432 hasConcept C185592680 @default.
• W2073753432 hasConcept C2522874641 @default.
• W2073753432 hasConcept C2776304256 @default.
• W2073753432 hasConcept C2780593183 @default.
• W2073753432 hasConcept C54009773 @default.
• W2073753432 hasConcept C54355233 @default.
• W2073753432 hasConcept C55493867 @default.
• W2073753432 hasConcept C71924100 @default.
• W2073753432 hasConcept C81885089 @default.
• W2073753432 hasConcept C86803240 @default.
• W2073753432 hasConceptScore W2073753432C101762097 @default.
• W2073753432 hasConceptScore W2073753432C104317684 @default.
• W2073753432 hasConceptScore W2073753432C105580179 @default.
• W2073753432 hasConceptScore W2073753432C111936080 @default.
• W2073753432 hasConceptScore W2073753432C126322002 @default.

• next