Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073764192> ?p ?o ?g. }
- W2073764192 endingPage "1106" @default.
- W2073764192 startingPage "1100" @default.
- W2073764192 abstract "Epstein–Barr virus (EBV)-associated diffuse large B-cell lymphoma (DLBCL) of the elderly constitutes a provisional clinicopathological entity in the current World Health Organization (WHO) classification and its genomic features remain sparsely characterized. We investigated a cohort of 26 cases of untreated de novo EBV-positive DLBCL of the elderly by high-resolution array-based comparative genomic profiling and fluorescence in situ hybridization (FISH). Moreover, we screened for activating mutations affecting nuclear factor (NF)-κB pathway signaling and chromatin remodeling (EZH2, CD79B, CARD11 and MYD88) due to their impact of gene expression signatures and postulated upcoming therapeutic targetability. We identified an overlap between genomic aberrations previously described to be exclusive features of plasmablastic lymphoma (PL), post-transplant lymphoproliferative disorder (PTLD) and DLBCL, respectively, indicating a close cytogenetic relationship between these entities. Few mutations affecting CD79B and CARD11 and no MYD88 mutations were detectable, hinting at EBV-mediated activation of NF-κB as an alternative to pathologically enforced B-cell receptor signaling in this rare entity." @default.
- W2073764192 created "2016-06-24" @default.
- W2073764192 creator A5011725019 @default.
- W2073764192 creator A5031928179 @default.
- W2073764192 creator A5042300762 @default.
- W2073764192 creator A5055216320 @default.
- W2073764192 creator A5057206849 @default.
- W2073764192 creator A5066771031 @default.
- W2073764192 creator A5079250860 @default.
- W2073764192 creator A5079892703 @default.
- W2073764192 creator A5081522201 @default.
- W2073764192 date "2014-08-21" @default.
- W2073764192 modified "2023-10-16" @default.
- W2073764192 title "Prevalence of targetable oncogenic mutations and genomic alterations in Epstein–Barr virus-associated diffuse large B-cell lymphoma of the elderly" @default.
- W2073764192 cites W1785108662 @default.
- W2073764192 cites W1951311182 @default.
- W2073764192 cites W1973628185 @default.
- W2073764192 cites W1979816280 @default.
- W2073764192 cites W1982925134 @default.
- W2073764192 cites W1993066858 @default.
- W2073764192 cites W1999021691 @default.
- W2073764192 cites W2004380688 @default.
- W2073764192 cites W2005578366 @default.
- W2073764192 cites W2006709900 @default.
- W2073764192 cites W2014485235 @default.
- W2073764192 cites W2017492512 @default.
- W2073764192 cites W2020094108 @default.
- W2073764192 cites W2024373518 @default.
- W2073764192 cites W2024728558 @default.
- W2073764192 cites W2030105242 @default.
- W2073764192 cites W2037904581 @default.
- W2073764192 cites W2042093631 @default.
- W2073764192 cites W2044306036 @default.
- W2073764192 cites W2045999289 @default.
- W2073764192 cites W2047053241 @default.
- W2073764192 cites W2050672588 @default.
- W2073764192 cites W2050820728 @default.
- W2073764192 cites W2053015113 @default.
- W2073764192 cites W2067257663 @default.
- W2073764192 cites W2084295010 @default.
- W2073764192 cites W2086618515 @default.
- W2073764192 cites W2095737226 @default.
- W2073764192 cites W2104308668 @default.
- W2073764192 cites W2116382435 @default.
- W2073764192 cites W2118184985 @default.
- W2073764192 cites W2127842142 @default.
- W2073764192 cites W2129738847 @default.
- W2073764192 cites W2136474149 @default.
- W2073764192 cites W2154747383 @default.
- W2073764192 cites W2158267770 @default.
- W2073764192 cites W2163990748 @default.
- W2073764192 cites W4210490242 @default.
- W2073764192 doi "https://doi.org/10.3109/10428194.2014.944522" @default.
- W2073764192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25030036" @default.
- W2073764192 hasPublicationYear "2014" @default.
- W2073764192 type Work @default.
- W2073764192 sameAs 2073764192 @default.
- W2073764192 citedByCount "37" @default.
- W2073764192 countsByYear W20737641922015 @default.
- W2073764192 countsByYear W20737641922016 @default.
- W2073764192 countsByYear W20737641922017 @default.
- W2073764192 countsByYear W20737641922018 @default.
- W2073764192 countsByYear W20737641922019 @default.
- W2073764192 countsByYear W20737641922020 @default.
- W2073764192 countsByYear W20737641922021 @default.
- W2073764192 countsByYear W20737641922022 @default.
- W2073764192 countsByYear W20737641922023 @default.
- W2073764192 crossrefType "journal-article" @default.
- W2073764192 hasAuthorship W2073764192A5011725019 @default.
- W2073764192 hasAuthorship W2073764192A5031928179 @default.
- W2073764192 hasAuthorship W2073764192A5042300762 @default.
- W2073764192 hasAuthorship W2073764192A5055216320 @default.
- W2073764192 hasAuthorship W2073764192A5057206849 @default.
- W2073764192 hasAuthorship W2073764192A5066771031 @default.
- W2073764192 hasAuthorship W2073764192A5079250860 @default.
- W2073764192 hasAuthorship W2073764192A5079892703 @default.
- W2073764192 hasAuthorship W2073764192A5081522201 @default.
- W2073764192 hasConcept C104317684 @default.
- W2073764192 hasConcept C124942203 @default.
- W2073764192 hasConcept C141231307 @default.
- W2073764192 hasConcept C167227067 @default.
- W2073764192 hasConcept C203014093 @default.
- W2073764192 hasConcept C2522874641 @default.
- W2073764192 hasConcept C2776995267 @default.
- W2073764192 hasConcept C2777542201 @default.
- W2073764192 hasConcept C2778559949 @default.
- W2073764192 hasConcept C2779338263 @default.
- W2073764192 hasConcept C2781246680 @default.
- W2073764192 hasConcept C2781375147 @default.
- W2073764192 hasConcept C30481170 @default.
- W2073764192 hasConcept C502942594 @default.
- W2073764192 hasConcept C54355233 @default.
- W2073764192 hasConcept C83640560 @default.
- W2073764192 hasConcept C86803240 @default.
- W2073764192 hasConceptScore W2073764192C104317684 @default.
- W2073764192 hasConceptScore W2073764192C124942203 @default.
- W2073764192 hasConceptScore W2073764192C141231307 @default.
- W2073764192 hasConceptScore W2073764192C167227067 @default.