FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073764997> ?p ?o ?g. }

• W2073764997 endingPage "716" @default.
• W2073764997 startingPage "710" @default.
• W2073764997 abstract "Management of oral cancer by radiotherapy has witnessed promising advances in the past few years, with patient-tailored radio fractionation regimens. Different fractionation schedules, conventional and altered regimes, have been used in curative radiotherapy. Although contribution of biological markers on radio response has been evaluated, its unique influence on various radio fractionation schemes has not been accounted so far. Our study analyses a set of proteins that previously demonstrated radio response influence for their possible prognostic value in decision-making process between the respective fractionation schemes. Expression patterns of regulatory proteins such as p53, cyclin D1, p16, Cdk4, p21, Rb, bcl-2 and PCNA were determined by immunohistochemistry utilizing monoclonal antibodies in 125 patients who received curative radiotherapy dose. Among these 125 patients, 90 (72%) received altered fractionation, whereas 35 (28%) received conventional fractionation. p53 over-expression correlated with local treatment failure among the patients treated with conventional fractionation whereas cyclin D1 over-expression and p16 underexpression were associated with local treatment failure as well as overall survival in altered fractionation treated cases. Our findings suggest that wild-type p53 status may be an important parameter for achieving high local control in those patients undergoing conventional fractionation, where as intact p16 and cyclin D1 status may be beneficial for effective local control in patients who are treated with altered fractionation. Furthermore, it can be assumed that conventional fractionation employs p53-mediated apoptosis, whereas altered fractionation activates the functional G1 cell-cycle checkpoint for tumor growth suppression. © 2004 Wiley-Liss, Inc." @default.
• W2073764997 created "2016-06-24" @default.
• W2073764997 creator A5028447404 @default.
• W2073764997 creator A5035922851 @default.
• W2073764997 creator A5037945265 @default.
• W2073764997 creator A5052312232 @default.
• W2073764997 creator A5054882485 @default.
• W2073764997 creator A5070598118 @default.
• W2073764997 creator A5089332274 @default.
• W2073764997 creator A5090408104 @default.
• W2073764997 date "2004-01-01" @default.
• W2073764997 modified "2023-10-16" @default.
• W2073764997 title "p53, p16 and cyclin D1: Molecular determinants of radiotherapy treatment response in oral carcinoma" @default.
• W2073764997 cites W1518376386 @default.
• W2073764997 cites W1789577188 @default.
• W2073764997 cites W1863595524 @default.
• W2073764997 cites W1967434204 @default.
• W2073764997 cites W1977706798 @default.
• W2073764997 cites W1981652313 @default.
• W2073764997 cites W1985875228 @default.
• W2073764997 cites W1995321234 @default.
• W2073764997 cites W2010196130 @default.
• W2073764997 cites W2018994731 @default.
• W2073764997 cites W2029137678 @default.
• W2073764997 cites W2030283142 @default.
• W2073764997 cites W2040375321 @default.
• W2073764997 cites W2041506960 @default.
• W2073764997 cites W2055078984 @default.
• W2073764997 cites W2060259713 @default.
• W2073764997 cites W2072392494 @default.
• W2073764997 cites W2073584782 @default.
• W2073764997 cites W2074981528 @default.
• W2073764997 cites W2085409346 @default.
• W2073764997 cites W2088652363 @default.
• W2073764997 cites W2090644399 @default.
• W2073764997 cites W2118722663 @default.
• W2073764997 cites W2120143983 @default.
• W2073764997 cites W2134542375 @default.
• W2073764997 cites W2164561295 @default.
• W2073764997 cites W2164678233 @default.
• W2073764997 cites W2175005119 @default.
• W2073764997 cites W2314971976 @default.
• W2073764997 cites W2335498674 @default.
• W2073764997 cites W2406213538 @default.
• W2073764997 cites W29671035 @default.
• W2073764997 cites W4323966477 @default.
• W2073764997 doi "https://doi.org/10.1002/ijc.20042" @default.
• W2073764997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14999779" @default.
• W2073764997 hasPublicationYear "2004" @default.
• W2073764997 type Work @default.
• W2073764997 sameAs 2073764997 @default.
• W2073764997 citedByCount "42" @default.
• W2073764997 countsByYear W20737649972012 @default.
• W2073764997 countsByYear W20737649972013 @default.
• W2073764997 countsByYear W20737649972014 @default.
• W2073764997 countsByYear W20737649972015 @default.
• W2073764997 countsByYear W20737649972016 @default.
• W2073764997 countsByYear W20737649972018 @default.
• W2073764997 countsByYear W20737649972019 @default.
• W2073764997 crossrefType "journal-article" @default.
• W2073764997 hasAuthorship W2073764997A5028447404 @default.
• W2073764997 hasAuthorship W2073764997A5035922851 @default.
• W2073764997 hasAuthorship W2073764997A5037945265 @default.
• W2073764997 hasAuthorship W2073764997A5052312232 @default.
• W2073764997 hasAuthorship W2073764997A5054882485 @default.
• W2073764997 hasAuthorship W2073764997A5070598118 @default.
• W2073764997 hasAuthorship W2073764997A5089332274 @default.
• W2073764997 hasAuthorship W2073764997A5090408104 @default.
• W2073764997 hasBestOaLocation W20737649971 @default.
• W2073764997 hasConcept C120089663 @default.
• W2073764997 hasConcept C121608353 @default.
• W2073764997 hasConcept C126322002 @default.
• W2073764997 hasConcept C143998085 @default.
• W2073764997 hasConcept C155806632 @default.
• W2073764997 hasConcept C178790620 @default.
• W2073764997 hasConcept C185592680 @default.
• W2073764997 hasConcept C199835354 @default.
• W2073764997 hasConcept C29537977 @default.
• W2073764997 hasConcept C502942594 @default.
• W2073764997 hasConcept C509974204 @default.
• W2073764997 hasConcept C71924100 @default.
• W2073764997 hasConcept C86803240 @default.
• W2073764997 hasConcept C97428945 @default.
• W2073764997 hasConceptScore W2073764997C120089663 @default.
• W2073764997 hasConceptScore W2073764997C121608353 @default.
• W2073764997 hasConceptScore W2073764997C126322002 @default.
• W2073764997 hasConceptScore W2073764997C143998085 @default.
• W2073764997 hasConceptScore W2073764997C155806632 @default.
• W2073764997 hasConceptScore W2073764997C178790620 @default.
• W2073764997 hasConceptScore W2073764997C185592680 @default.
• W2073764997 hasConceptScore W2073764997C199835354 @default.
• W2073764997 hasConceptScore W2073764997C29537977 @default.
• W2073764997 hasConceptScore W2073764997C502942594 @default.
• W2073764997 hasConceptScore W2073764997C509974204 @default.
• W2073764997 hasConceptScore W2073764997C71924100 @default.
• W2073764997 hasConceptScore W2073764997C86803240 @default.
• W2073764997 hasConceptScore W2073764997C97428945 @default.
• W2073764997 hasIssue "5" @default.

• next