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• W2073770185 abstract "Background: A sensitive and reproducible Ultra High Performance Liquid Chromatography-Tandem Mass Spectrometry method has been developed for the simultaneous quantification of the 29 commonly prescribed benzodiazepines and z-drugs in hair. The method was validated according to international guidelines. Methods: After decontamination (with dichloromethane and water), compounds were extracted from 20 mg of pulverized hair samples using methanol at 45°C and sonication for 2 hours. The drugs were recovered by liquid–liquid extraction using 1-chlorobutane, evaporated to dryness, and reconstituted with 100 μL of methanol before injection in the UPLC–MS/MS. Results: The applied gradient ensured the elution of all the compounds within 7 minutes using 0.1% formic acid in water and methanol as mobile phase. The lower limit of quantification values ranged from 0.5 to 5 pg/mg of hair. Calibration curves were linear for almost all the compounds and ranged from the limit of quantification to 620 pg/mg hair. The bias and relative standard deviation of the intraday and interday imprecision were lower than 15% in 3 fortified “in-house” quality control samples, 1 external quality control sample, and 1 authentic hair sample (from a diazepam user). No significant matrix effects were observed for most of the compounds, and the extraction efficiency of the sample cleanup procedure ranged from 19% to 82% with a relative standard deviation <15% [except for clobazam (16%), loprazolam (20%), brotizolam (18%), and 7-aminoclonazepam (20%)]. The method was then successfully applied to the analysis of 40 hair samples from the workplace drug testing, containing alprazolam, estazolam, clonazepam, diazepam, zolpidem, and desalkylflurazepam (and metabolites). Conclusions: The method was completely validated and can be of interest to clinical and forensic laboratories." @default.
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• W2073770185 date "2015-10-01" @default.
• W2073770185 modified "2023-10-16" @default.
• W2073770185 title "Detection of Benzodiazepines and z-Drugs in Hair Using an UHPLC-MS/MS Validated Method" @default.
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• W2073770185 doi "https://doi.org/10.1097/ftd.0000000000000188" @default.
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