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- W2073770516 abstract "The design and synthesis of a series of pyrrolo[2,1-c][1,4]benzodiazepine (PBD)- polyaminoalkyl conjugates as DNA minor groove binders are described. To introduce polyaminoalkyl groups to the pyrrolo[2,1-c][1,4]benzodiazepine pharmacophore, S N Ar reactions between 2-nitro-5-fluorophenyl ketone or 2-nitro-3-pehenyl ketone and polyaminoalkyl side chains were developed." @default.
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- W2073770516 date "2004-01-01" @default.
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- W2073770516 title "Design and Synthesis of Pyrrolo-[2,1-c][1,4]benzodiazepine (PBD)-Polyaminoalkyl Conjugates by the Use of SNAr Reaction of 2-Nitro-5-fluorobenzoate Precursor as Key Reaction" @default.
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- W2073770516 doi "https://doi.org/10.3987/com-03-s(p)69" @default.
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