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- W2073781316 abstract "PAI-1 (plasminogen activator inhibitor-1) in breast cancer cells is involved in tumour development and metastasis of breast cancer cells. PAI-1 function and the regulation of its expression have been precisely investigated. Here we report that EGF, which promotes breast cancer tumour growth and survival, rapidly induces PAI-1 expression in the breast adenocarcinoma cell line MCF-7 through the activation of the transcription factor Elk-1. We have found that the PAI-1 promoter fragment (−140 to + 173) containing the Ets consensus binding site is activated by Elk-1. Chromatin immunoprecipitation analysis confirms in vivo binding of Elk-1 to the PAI-1 promoter and demonstrates that Elk-1 phosphorylation on the Ets binding site is EGF-dependent." @default.
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- W2073781316 date "2010-09-01" @default.
- W2073781316 modified "2023-10-13" @default.
- W2073781316 title "Epidermal growth factor regulates PAI-1 expression via activation of the transcription factor Elk-1" @default.
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- W2073781316 doi "https://doi.org/10.1016/j.bbagrm.2010.08.004" @default.
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